Evidence map›Paper›PMID 30741945›Full record

ArticleTranslational psychiatry2019

Cigarette smoking and gray matter brain volumes in middle age adults: the CARDIA Brain MRI sub-study.

Martine Elbejjani, Reto Auer, David R Jacobs, Thaddeus Haight, Christos Davatzikos, David C Goff, R Nick Bryan, Lenore J Launer

Open access · goldAbstract read
In one paragraph

Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 73 citations in OpenAlex.

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  13. Associations and interactions betweenBrain communications · 2025
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  20. Association of smoking with brain gray and white matter volume: a Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Martine ElbejjaniLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA.
Reto AuerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
David R JacobsDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-7232-0543
Thaddeus HaightLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA.
Christos DavatzikosDepartment of Radiology, University of Pennsylvania Health System, Philadelphia, PA, USA.
David C GoffNational Heart, Lung, and Blood Institute, Bethesda, MD, USA.
R Nick BryanDepartment of Radiology, University of Pennsylvania Health System, Philadelphia, PA, USA.
Lenore J LaunerLaboratory of Epidemiology and Population Science, National Institute on Aging, Bethesda, MD, USA. launerl@nia.nih.gov.
National Institute on Aging · USUniversity of Pennsylvania Health System · USNational Heart Lung and Blood Institute · USUniversity of Bern · CHUniversity of Minnesota · US

Funding

Machine Learning and Large-scale Imaging analytics for dimensional representations of brain trajectories in aging and preclinical Alzheimer's Disease: The brain aging chart and the iSTAGING consortiumRF1AG054409 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DAVATZIKOS, CHRISTOS · 2017 to 2023
$6.3M
NHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNIA NIH HHS RF1 AG054409
6 · The paper itself

Abstract

Cigarette smoking has been associated with dementia and dementia-related brain changes, notably gray matter (GM) volume atrophy. These associations are thought to reflect the co-morbidity of smoking and vascular, respiratory, and substance use/psychological conditions. However, the extent and localization of the smoking-GM relationship and the degree to which vascular, respiratory, and substance use/psychological factors influence this relationship remain unclear. In the Coronary Artery Risk Development in Young Adults CARDIA cohort (n = 698; 52% women; 40% black participants; age = 50.3 (SD = 3.5)), we examined the associations of smoking status with total GM volume and GM volume of brain regions linked to neurocognitive and addiction disorders. Linear regression models were used to adjust for vascular, respiratory, and substance use/psychological factors and to examine whether they modify the smoking-GM relationship. Compared to never-smokers, current smokers had smaller total GM volume (-8.86 cm

Indexed as

Alcohol DrinkingBrainCigarette SmokingFemaleGray MatterHumansMagnetic Resonance ImagingMaleMiddle AgedRisk FactorsSubstance-Related Disorders

Identifiers

PMID30741945
PMCPMC6370765
OpenAlexW2913683155

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.