ReviewThe Journal of clinical investigation2019
Environmental exposures and mechanisms in allergy and asthma development.
Review in The Journal of clinical investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04902989 (Association Between Environmental Pollutants and Their Effects on Respiratory), which is not on this map. Cited by 177 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association Between Environmental Pollutants and Their Effects on Respiratory
Who cites it
177 citing papers in PubMed, 8 syntheses or guidelines pooled it, 374 citations in OpenAlex.
- Prevalence and risk factors for asthma in East Africa: a systematic review and meta-analysis.BMC pediatrics · 2026Pooled it
- Association between early-life antibiotic exposure and gut microbiome alterations linked to allergic diseases in children: a systematic review.European journal of medical research · 2025Pooled it
- Childhood obesity and allergic rhinitis: A meta-analysis.Biomolecules & biomedicine · 2025Pooled it
- Prenatal Exposure to Air Pollutants Associated with Allergic Diseases in Children: Which Pollutant, When Exposure, and What Disease? A Systematic Review and Meta-analysis.Clinical reviews in allergy & immunology · 2024Pooled it
- The Association between Migration and Prevalence of Allergic Diseases: A Systematic Review and Meta-Analysis.International archives of allergy and immunology · 2024Pooled it
- Exposure to Heavy Metals and Allergic Outcomes in Children: a Systematic Review and Meta-analysis.Biological trace element research · 2022Pooled it
- Association between exposure to greenness and atopic march in children and adults-A systematic review and meta-analysis.Frontiers in public health · 2022Pooled it
- Association between childhood asthma and history of assisted reproduction techniques: a systematic review and meta-analysis.European journal of pediatrics · 2021Pooled it
- Effects of short-term exposure to air pollution on respiratory symptoms and lung function among patients with asthma.Medical gas research · 2026Article
- Unraveling the increasing burden of allergies: Spatiotemporal dynamics of pollen allergy risk in China.Eco-Environment & Health · 2026Article
- Early Life Exposure to PFOS or F‑53B is Associated with Increased Asthma Susceptibility in Offspring and Alterations in the Pulmonary Barrier, Immune Function, and Gut Microbiota.Environment & health (Washington, D.C.) · 2026Article
- Early-life immune imprinting by a B. infantis-HMO synbiotic shapes infant immune signatures and protects against experimental respiratory disease.Cell reports. Medicine · 2026Article
- Role and mechanism of quercetin via the TLR4/MyD88/IRAK4 signaling pathway in the treatment of allergic rhinitis.Experimental and therapeutic medicine · 2026Article
- Relative contributions of meteorological factors and atmospheric pollutants to childhood adenoid hypertrophy: A time-series study in Chongqing, China.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
- Association of atopic multimorbidity with childhood pet exposure and caesarean section delivery: a retrospective study from the Lifelines Cohort Study.Skin health and disease · 2026Article
- Relative contributions of climate factors and air pollution to childhood allergic diseases in Chongqing, China.BMC public health · 2026Article
- Prevalence and factors associated with self-reported asthma diagnosis in Makkah Region of Saudi Arabia.Medicine · 2026Article
- Indoor building materials and household chemical products in Chinese homes are associated with current asthma and allergic symptoms in children.Journal of exposure science & environmental epidemiology · 2026Article
- Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Prophylactic Inhaled Pattern Recognition Receptor Agonists Reprogram Lung Epithelial Response and Prevent Type 2 Allergic Inflammation.European journal of immunology · 2026Article
117 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Environmental exposures interplay with human host factors to promote the development and progression of allergic diseases. The worldwide prevalence of allergic disease is rising as a result of complex gene-environment interactions that shape the immune system and host response. Research shows an association between the rise of allergic diseases and increasingly modern Westernized lifestyles, which are characterized by increased urbanization, time spent indoors, and antibiotic usage. These environmental changes result in increased exposure to air and traffic pollution, fungi, infectious agents, tobacco smoke, and other early-life and lifelong risk factors for the development and exacerbation of asthma and allergic diseases. It is increasingly recognized that the timing, load, and route of allergen exposure affect allergic disease phenotypes and development. Still, our ability to prevent allergic diseases is hindered by gaps in understanding of the underlying mechanisms and interaction of environmental, viral, and allergen exposures with immune pathways that impact disease development. This Review highlights epidemiologic and mechanistic evidence linking environmental exposures to the development and exacerbation of allergic airway responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.