Evidence map›Paper›PMID 30741480›Full record

ArticleObesity (Silver Spring, Md.)2019

Genetic Architecture of Human Obesity Traits in the Rhesus Macaque.

Michael J Raboin, John Letaw, Asia D Mitchell, David Toffey, Jessica McKelvey, Charles T Roberts, Joanne E Curran, Amanda Vinson

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obesity (Silver Spring, Md.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Michael J RaboinPrimate Genetics Section, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
John LetawPrimate Genetics Section, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Asia D MitchellPrimate Genetics Section, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
David ToffeyPrimate Genetics Section, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Jessica McKelveyDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Charles T RobertsDivision of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.
Joanne E CurranSouth Texas Diabetes and Obesity Institute and Department of Human Genetics, University of Texas Rio Grande Valley School of Medicine, Brownsville, Texas, USA.
Amanda VinsonPrimate Genetics Section, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, Oregon, USA.ORCID 0000-0001-9955-8052

Funding

Upgrade of confocal microscopy at the Oregon National Primate Research CenterP51OD011092 · OD · OREGON HEALTH & SCIENCE UNIVERSITY · PI Bonnie J. Nagel · 2012 to 2026
$203.9M
NIH HHS P51 OD011092
6 · The paper itself

Abstract

objectiveWhereas the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are nonexistent. This study assessed genetic contributions to spontaneous adiposity in this species.

methodsPhenotypic variation by age class and sex for BMI, waist to height ratio, waist to thigh ratio, and waist circumference was assessed in 583 macaques. Total and sex-specific heritability for all traits was estimated, including waist to thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. In addition, functional genetic variation at BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and SIM1 was assessed in four animals with extreme spontaneous adiposity.

resultsTrait heritability in the combined sample was low to moderate (0.14-0.32), whereas sex-specific heritability was more substantial (0.20-0.67). Heritability was greater in females for all traits except BMI. All traits were robustly correlated, with genetic correlations of 0.63 to 0.93 indicating substantial pleiotropy. Likely functional variants were discovered in the four macaques at all eight human obesity genes, including six missense mutations in BDNF, FTO, LEP, LEPR, and PCSK1 and, notably, one nonsense mutation in LEPR.

conclusionsA moderate polygenic contribution to adiposity in rhesus macaques was found, as well as mutations with potentially larger effects in multiple genes that influence obesity in humans.

Indexed as

AdolescentAdultAgedAnimalsChildChild, PreschoolHumansMacaca mulattaMiddle AgedObesityYoung Adult

Identifiers

PMID30741480
PMCPMC6389383

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.