Evidence map›Paper›PMID 30741341›Full record

ArticleMikrochimica acta2019

Voltammetric immunosensor for E-cadherin promoter DNA methylation using a Fe

Roya Khodaei, Anita Ahmady, Seyyed Mehdi Khoshfetrat, Soheila Kashanian, Seyed Mohammad Tavangar, Kobra Omidfar

Abstract read
PubMed Publisher
In one paragraph

Article in Mikrochimica acta, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 56 citations in OpenAlex.

  1. Review
  2. Recent Advances in the Electrochemical Biosensing of DNA Methylation.International journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Roya KhodaeiBiosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Islamic Republic of Iran.
Anita AhmadyBiosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Islamic Republic of Iran.
Seyyed Mehdi KhoshfetratBiosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Islamic Republic of Iran.
Soheila KashanianNano Drug Delivery Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Seyed Mohammad TavangarDepartment of Pathology, Shariati Hospital, Tehran University of Medical Science, 1411713135, Tehran, Iran.
Kobra OmidfarBiosensor Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, P.O. Box 14395/1179, Tehran, Islamic Republic of Iran. omidfar@tums.ac.ir.ORCID http://orcid.org/0000-0002-8831-6936
Tehran University of Medical Sciences · IRRazi University · IRUniversity of Tehran · IR

Funding

Institut National des Sciences de l'Univers, Centre National de la Recherche Scientifique (FR) 958253
6 · The paper itself

Abstract

Silencing of tumor suppressor genes (E-cadherin) by promoter DNA methylation may lead to the development of invasive phenotypes in epithelial tissues. The authors describe an electrochemical nanobiosensor for early detection and screening of circulating methylated DNA as a biomarker for cancers. First, the antibody against 5-methylcytosine was physically immobilized onto modified with reduced graphene oxide and polyvinylalcohol. In the next step, methylated target DNA in samples was hybridized with ssDNA probe conjugated to Fe

Indexed as

DNA MethylationPromoter Regions, GeneticAntigens, CDBiomarkers, TumorCadherinsCell-Free Nucleic AcidsCitric AcidElectrochemical TechniquesElectrodesFerric CompoundsGraphiteHumansNanocompositesNeoplasmsPolyvinyl AlcoholAntigens, CDBiomarkers, TumorCadherinsCDH1 protein, humanCell-Free Nucleic AcidsCitric AcidFerric Compoundsferric oxideGraphitePolyvinyl AlcoholAnti-5-methylcytosine antibodyDNA methylationDNA nanobiosensorMagnetic nanoparticleNanocomposite

Identifiers

PMID30741341
OpenAlexW2914159997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.