Evidence map›Paper›PMID 30741022›Full record

ArticleIntegrative cancer therapies

Impaired Postural Control and Altered Sensory Organization During Quiet Stance Following Neurotoxic Chemotherapy: A Preliminary Study.

Scott M Monfort, Xueliang Pan, Charles L Loprinzi, Maryam B Lustberg, Ajit M W Chaudhari

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04692168 (Influence of Chemotherapy on Postural Control and Quality of Life in Women With Gynaecological Cancer), which is not on this map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04692168 completednot on this map

Influence of Chemotherapy on Postural Control and Quality of Life in Women With Gynaecological Cancer: a Prospective Observational Study

TypeobservationalSponsorAline ReinmannRan2020 to 2022Enrolled35ConditionsCancer, Breast, Cancer, Gynecologic
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
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  20. A review of movement disorders in chemotherapy-induced neurotoxicity.Journal of neuroengineering and rehabilitation · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Scott M Monfort1 Montana State University, Bozeman, MT, USA.ORCID 0000-0001-5270-0592
Xueliang Pan2 The Ohio State University, Columbus, OH, USA.
Charles L Loprinzi3 Mayo Clinic, Rochester, MN, USA.
Maryam B Lustberg2 The Ohio State University, Columbus, OH, USA.
Ajit M W Chaudhari2 The Ohio State University, Columbus, OH, USA.
The Ohio State University · USMayo Clinic in Arizona · USMontana State University · US

Funding

The OSU Center for Clinical and Translational Science: Advancing Today's Discoveries to Improve HealthUL1TR002733 · NCATS · OHIO STATE UNIVERSITY · PI RINGEL, MATTHEW D · 2018 to 2022
$28.9M
Gait and Balance Changes in Chemotherapy Induced Peripheral NeuropathyR03CA182165 · NCI · OHIO STATE UNIVERSITY · PI CHAUDHARI, AJIT MOHAN WORTHEN, LUSTBERG, MARYAM B. · 2014 to 2015
$154k
NCATS NIH HHS UL1 TR002733NCI NIH HHS R03 CA182165
6 · The paper itself

Abstract

Individuals diagnosed with chemotherapy-induced peripheral neuropathy (CIPN) demonstrate impaired balance and carry an increased risk of falling. However, prior investigations of postural instability have only compared these individuals against healthy controls, limiting the understanding of impairments associated with CIPN. Therefore, the purpose of this study was to better isolate postural control impairments that are associated with CIPN. Twenty cancer survivors previously diagnosed with breast or colorectal cancer participated. Participants were separated into 3 groups: no prior chemotherapy exposure (CON, n = 6), and recent treatment with taxane- or oxaliplatin-based chemotherapy with no/mild symptoms of CIPN (-CIPN, n = 8) or moderate/severe symptoms of CIPN (+CIPN, n = 6). Postural control was assessed by measuring center of pressure during standing balance conditions that systematically interfered with somatosensory, visual, and/or vestibular information. The presence of CIPN sensory symptoms was associated with impaired postural control, particularly during eyes-closed balance conditions ( P < .05). Additionally, medial-lateral postural instability was more pronounced in the +CIPN group compared with the -CIPN group and CON participants ( P < .05). Greater postural instability during eyes-closed balance in individuals with CIPN is consistent with impaired peripheral sensation. Balance impairments in cancer survivors with CIPN demonstrate the unique challenges in this population and motivate the need for targeted efforts to mitigate postural control deficits that have previously been associated with fall risk.

Indexed as

Accidental FallsAntineoplastic AgentsBreast NeoplasmsBridged-Ring CompoundsCancer SurvivorsColorectal NeoplasmsFemaleHumansMaleMiddle AgedOxaliplatinPeripheral Nervous System DiseasesPostural BalanceTaxoidsAntineoplastic AgentsBridged-Ring CompoundsOxaliplatintaxaneTaxoidsbalancecenter of pressurechemotherapy-induced peripheral neuropathyCIPNsensory reweighting

Identifiers

PMID30741022
PMCPMC7242799
OpenAlexW2913056912

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.