Evidence map›Paper›PMID 30740984›Full record

ArticleAmerican journal of Alzheimer's disease and other dementias2019

Excessive Daytime Sleepiness in Major Dementia Syndromes.

Angelica Boeve, Tanis J Ferman, Jeremiah Aakre, Erik St Louis, Michael Silber, Mary Machulda, Julie Fields, Neill Graff-Radford, Michelle Mielke, Yonas Geda and 5 more

Open access · bronzeAbstract read
In one paragraph

Article in American journal of Alzheimer's disease and other dementias, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.

  1. Sleep disturbances in Lewy body dementia: A systematic review.International journal of geriatric psychiatry · 2022
    Pooled it
  2. A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Review
  3. Article
  4. Article
  5. Role of sleep in neurodegeneration: the consensus report of the 5th Think Tank World Sleep Forum.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. The Relationship Between Light Exposure before Bedtime and Daytime Sleepiness Among People Living With Cognitive Impairment.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022
    Article
  12. Article
  13. Early Alert of Elderly Cognitive Impairment using Temporal Streaming Clustering.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2021
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Angelica Boeve1 Mayo Clinic, Rochester, MN, USA.
Tanis J Ferman2 Mayo Clinic, Jacksonville, FL, USA.
Jeremiah Aakre1 Mayo Clinic, Rochester, MN, USA.
Erik St Louis1 Mayo Clinic, Rochester, MN, USA.
Michael Silber1 Mayo Clinic, Rochester, MN, USA.
Mary Machulda1 Mayo Clinic, Rochester, MN, USA.
Julie Fields1 Mayo Clinic, Rochester, MN, USA.
Neill Graff-Radford2 Mayo Clinic, Jacksonville, FL, USA.
Michelle Mielke1 Mayo Clinic, Rochester, MN, USA.
Yonas Geda3 Mayo Clinic, Scottsdale, AZ, USA.
David Jones1 Mayo Clinic, Rochester, MN, USA.
Jonathon Graff-Radford1 Mayo Clinic, Rochester, MN, USA.
David Knopman1 Mayo Clinic, Rochester, MN, USA.
Ronald Petersen1 Mayo Clinic, Rochester, MN, USA.
Brad Boeve1 Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-4153-8187
Mayo Clinic in Arizona · USWinnMed · US

Funding

THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
NEUROPSYCHOLOGY OF DEMENTIA WITH LEWY BODIESR01AG015866 · NIA · MAYO CLINIC JACKSONVILLE · PI FERMAN, TANIS JILL · 1999 to 2009
$2.6M
Pathways linking neuropsychiatric symptoms with Alzheimer's disease neuroimaging biomarkers and the outcome of incident Mild Cognitive Impairment/ DementiaR01AG057708 · NIA · ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER · PI GEDA, YONAS E · 2018 to 2022
$1.7M
NIA NIH HHS P50 AG016574NIA NIH HHS R01 AG015866NIA NIH HHS R01 AG057708
6 · The paper itself

Abstract

There has been no comparison of excessive daytime sleepiness (EDS) in patients with Alzheimer's disease dementia (AD), dementia with Lewy bodies (DLB), and behavioral variant frontotemporal dementia (bvFTD). We identified patients with mild dementia who met criteria for these disorders who also had the Epworth Sleepiness Scale (ESS) completed. The sample included 17 bvFTD, 111 AD, and 31 DLB. An ESS score ≥10 was considered abnormal and consistent with EDS. Analyses with age and sex as covariates revealed higher mean ESS scores for DLB compared to the other groups (DLB 13.9 [5], bvFTD 9.6 [8], AD 8.8 [5], P < .05). An ESS score ≥10 was significantly more likely to occur in DLB compared to bvFTD or AD (DLB 81% vs bvFTD 47% vs AD 45%, P < .01). In patients with mild dementia, EDS is greatest in DLB and comparably lower in bvFTD and AD.

Indexed as

Disorders of Excessive SomnolenceAgedDementiaFemaleFrontotemporal DementiaHumansLewy Body DiseaseMalePsychiatric Status Rating ScalesRisk FactorsAlzheimer’s diseasedementia with Lewy bodiesexcessive daytime sleepinessfrontotemporal dementia

Identifiers

PMID30740984
PMCPMC6709580
OpenAlexW2911909781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.