Evidence map›Paper›PMID 30740834›Full record

ReviewNeurogastroenterology and motility2019

Advances in the physiology of gastric emptying.

Raj K Goyal, Yanmei Guo, Hiroshi Mashimo

Registry-linked trialOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurogastroenterology and motility, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05711758 (Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure), which is not on this map. Cited by 166 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
166citing papers in PubMed, 5 pooled it
21.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05711758 recruitingnot on this mapstarted 2023, after this paper: background citation

Efficacy and Safety of Endoscopic Antral Myotomy as a Novel Weight Loss Procedure: A Pilot Study

TypeobservationalSponsorChristopher C. Thompson, MD, MScRan2023 to 2027Enrolled30ConditionsObesity, Obesity, Morbid, Obesity, Primary, Metabolic DiseaseArmsPSAM Treatment Patients
3 · Its place in the literature

Who cites it

166 citing papers in PubMed, 5 syntheses or guidelines pooled it, 355 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Trial
  8. Trial
  9. Trial
  10. Trial
  11. Trial
  12. BMC gastroenterology · 2020
    Trial
  13. Trial
  14. Review
  15. Article
  16. Effect of GLP-1 receptor agonist on nutrient intake: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026
    Review
  17. Article
  18. Article
  19. Preoperative fasting guidelines: A narrative review.European journal of anaesthesiology and intensive care · 2026
    Review
  20. Review

106 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Raj K GoyalDepartment of Medicine, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-0066-6932
Yanmei GuoDepartment of Medicine, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0001-8711-0699
Hiroshi MashimoDepartment of Medicine, VA Boston Healthcare System, Harvard Medical School, Boston, Massachusetts.ORCID 0000-0002-6132-6771
Harvard University · US

Funding

Pathophysiology of Diabetic GastroparesisI01BX002806 · VA · VA BOSTON HEALTH CARE SYSTEM · PI GOYAL, RAJ K · 2016 to 2020
–
BLRD VA I01 BX002806Merit Award from the VA Medical Research Service, Department of Veterans Affairs, Washington, DC (RKG) 5101 BX002806-04William S Middleton Award from the Department of Veterans Affairs, Office of Research and Development, Biomedical Research Laboratory, and Development Service (RKG).
6 · The paper itself

Abstract

There have been many recent advances in the understanding of various aspects of the physiology of gastric motility and gastric emptying. Earlier studies had discovered the remarkable ability of the stomach to regulate the timing and rate of emptying of ingested food constituents and the underlying motor activity. Recent studies have shown that two parallel neural circuits, the gastric inhibitory vagal motor circuit (GIVMC) and the gastric excitatory vagal motor circuit (GEVMC), mediate gastric inhibition and excitation and therefore the rate of gastric emptying. The GIVMC includes preganglionic cholinergic neurons in the DMV and the postganglionic inhibitory neurons in the myenteric plexus that act by releasing nitric oxide, ATP, and peptide VIP. The GEVMC includes distinct gastric excitatory preganglionic cholinergic neurons in the DMV and postganglionic excitatory cholinergic neurons in the myenteric plexus. Smooth muscle is the final target of these circuits. The role of the intramuscular interstitial cells of Cajal in neuromuscular transmission remains debatable. The two motor circuits are differentially regulated by different sets of neurons in the NTS and vagal afferents. In the digestive period, many hormones including cholecystokinin and GLP-1 inhibit gastric emptying via the GIVMC, and in the inter-digestive period, hormones ghrelin and motilin hasten gastric emptying by stimulating the GEVMC. The GIVMC and GEVMC are also connected to anorexigenic and orexigenic neural pathways, respectively. Identification of the control circuits of gastric emptying may provide better delineation of the pathophysiology of abnormal gastric emptying and its relationship to satiety signals and food intake.

Indexed as

AnimalsEnteric Nervous SystemGastric EmptyingGastrointestinal MotilityGhrelinHumansMotilinNeuronsGhrelinMotilindigestive and inter-digestive periodsgastric emptyinggastric motilityintestinal hormonesneural controlsatiety and food intakethe interstitial cell of Cajalvagal circuits

Identifiers

PMID30740834
PMCPMC6850045
OpenAlexW2914264761

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.