Trial reportTransfusion medicine (Oxford, England)2019
Transfusion service knowledge and immunohaematological practices related to sickle cell disease and thalassemia.
Trial report in Transfusion medicine (Oxford, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Survey of Red Cell Transfusion Therapy and Immunohematology Services for Patients with Hemoglobinopathies in TürkiyeTurkish journal of haematology : official journal of Turkish Society of Haematology · 2025Article
- Red cell alloimmunization is associated with increased health care costs, longer hospitalizations, and higher mortality.Blood advances · 2022Article
- Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal.Haematologica · 2020Article
- Transfusion Support in Patients with Hematologic Disease: New and Novel Transfusion Modalities.Seminars in hematology · 2019Article
- Red Cell Transfusions in the Genomics Era.Seminars in hematology · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectivesTo assess current knowledge of National Heart, Lung and Blood Institutes (NHLBI) and Thalassemia International Federation (TIF) recommendations, blood banking practices and perceived challenges among transfusion services in the management of patients with haemoglobinopathies.
backgroundPrevious reports have demonstrated variations in transfusion practices for sickle cell disease (SCD) and thalassemia patients. Recently, NHLBI/TIF have provided transfusion recommendations for patients with haemoglobinopathies.
methodsA cross-sectional survey was conducted of transfusion services from the state of Georgia previously identified as having SCD/thalassemia populations. The survey assessed transfusion service practices in pre-transfusion testing and blood product selection; awareness/implementation of NHLBI/TIF transfusion-based recommendations and perceived challenges in transfusing haemoglobinopathy patients.
resultsResponses were received from 35 of 49 (71%) institutions. Only institutions indicating transfusing SCD or thalassemia patients (32) were included in analysis. Seventy-one percent of non-sickle cell treatment centres (SCTCs) and 20% of non-thalassemia treatment centres follow NHLBI and TIF recommendations to perform a red blood cell phenotype beyond ABO/Rh(D) and provide Rh and Kell prophylactically matched units for SCD and thalassemia patients, respectively. Forty percent of institutions (33% of non-SCTCs) employ RBC genotyping to evaluate the red cell phenotype for SCD patients. Over 77% of institutions do not utilise a reliable method to identify SCD patients prior to transfusion, such as a required question/answer field on type/screen or crossmatch orders.
conclusionMany healthcare systems' transfusion practices for haemoglobinopathy patients are discordant with NHLBI/TIF recommendations. Efforts are needed to increase awareness and implementation of current recommendations among all transfusion services seeing these patients.
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