ArticleEpilepsia2019
Functional MRI and direct cortical stimulation: Prediction of postoperative language decline.
Article in Epilepsia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The utilisation of fMRI for pre-operative mapping in the paediatric population with central nervous system tumours: a systematic review.Neuroradiology · 2025Pooled it
- Roles of fMRI and Wada tests in the presurgical evaluation of language functions in temporal lobe epilepsy.Frontiers in neurology · 2022Pooled it
- Electrical Cortical Stimulation for Language Mapping in Epilepsy Surgery-A Systematic Review.Brain sciences · 2025Review
- Challenges and opportunities for advancing functional MRI in clinical practice.Brain : a journal of neurology · 2025Article
- Consensus recommendations for clinical functional MRI applied to language mapping.Aperture neuro · 2025Article
- Mapping Cognition in Epilepsy: From the Lab to the Clinic.Epilepsy currents · 2024Review
- Language Lateralization by Passive Auditory fMRI in Presurgical Assessment for Temporal Lobe Epilepsy: A Single-Center Retrospective Study.Journal of clinical medicine · 2024Article
- Neurological update: structural and functional imaging in epilepsy surgery.Journal of neurology · 2023Review
- Determination of language areas in patients with epilepsy using the super-selective Wada test.IBRO neuroscience reports · 2022Article
- Combination of Multimodal MRI, Neuronavigation, and Awake Craniotomy in Removing Tumors of Eloquent Areas.Sovremennye tekhnologii v meditsine · 2022Article
- Pediatric awake epilepsy surgery: Intraoperative language mapping utilizing digital video gaming and electrocorticography.Epilepsy & behavior reports · 2022Article
- Feasibility, Contrast Sensitivity and Network Specificity of Language fMRI in Presurgical Evaluation for Epilepsy and Brain Tumor Surgery.Brain topography · 2021Article
- Language lateralization from task-based and resting state functional MRI in patients with epilepsy.Human brain mapping · 2020Article
- Functional Near-Infrared Spectroscopy and Its Clinical Application in the Field of Neuroscience: Advances and Future Directions.Frontiers in neuroscience · 2020Review
- Naming fMRI predicts the effect of temporal lobe resection on language decline.Annals of clinical and translational neurology · 2019Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
objectiveTo assess the ability of functional MRI (fMRI) to predict postoperative language decline compared to direct cortical stimulation (DCS) in epilepsy surgery patients.
methodsIn this prospective case series, 17 patients with drug-resistant epilepsy had intracranial monitoring and resection from 2012 to 2016 with 1-year follow-up. All patients completed preoperative language fMRI, mapping with DCS of subdural electrodes, pre- and postoperative neuropsychological testing for language function, and resection. Changes in language function before and after surgery were assessed. fMRI activation and DCS electrodes in the resection were evaluated as potential predictors of language decline.
resultsFour of 17 patients (12 female; median [range] age, 43 [23-59] years) experienced postoperative language decline 1 year after surgery. Two of 4 patients had overlap of fMRI activation, language-positive electrodes in basal temporal regions (within 1 cm), and resection. Two had overlap between resection volume and fMRI activation, but not DCS. fMRI demonstrated 100% sensitivity and 46% specificity for outcome compared to DCS (50% and 85%, respectively). When fMRI and DCS language findings were concordant, the combined tests showed 100% sensitivity and 75% specificity for language outcome. Seizure-onset age, resection side, type, volume, or 1 year seizure outcome did not predict language decline. SIGNIFICANCE: Language localization overlap of fMRI and direct cortical stimulation in the resection influences postoperative language performance. Our preliminary study suggests that fMRI may be more sensitive and less specific than direct cortical stimulation. Together they may predict outcome better than either test alone.
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