Evidence map›Paper›PMID 30740685›Full record

ArticleJournal of anatomy2019

Multimodal imaging assessment and histologic correlation of the female rat pelvic floor muscles' anatomy.

Vipul R Sheth, Pamela Duran, Jonathan Wong, Sameer Shah, Jiang Du, Karen L Christman, Eric Y Chang, Marianna Alperin

Open access · bronzeAbstract read
In one paragraph

Article in Journal of anatomy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Current practice in animal models for pelvic floor dysfunction.International urogynecology journal · 2023
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Vipul R ShethDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Pamela DuranDepartment of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, USA.
Jonathan WongDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Sameer ShahDepartment of Orthopedic Surgery, University of California San Diego, La Jolla, CA, USA.
Jiang DuDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Karen L ChristmanDepartment of Bioengineering, Sanford Consortium for Regenerative Medicine, University of California San Diego, La Jolla, CA, USA.
Eric Y ChangDepartment of Radiology, University of California San Diego, La Jolla, CA, USA.
Marianna AlperinDivision of Female Pelvic Medicine and Reconstructive Surgery, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0002-6004-1803
University of California San Diego · US

Funding

UC San Diego Clinical and Translational Research InstituteUL1TR001442 · NCATS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI FIRESTEIN, GARY S, HOGARTH, MICHAEL · 2015 to 2024
$88.3M
UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1M
Mechanisms and Impact of Pregnancy-Induced Adaptations in Pelvic Floor MusclesR01HD092515 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2017 to 2025
$4.0M
Traning Clinical Scientists in Radiological ImagingT32EB005970 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Eric Y Chang, Rebecca Ann Rakow-Penner · 2007 to 2026
$3.2M
Injectable Tissue-Specific Extracellular Matrix Hydrogel for Pelvic Skeletal Muscle Regeneration Following Birth InjuryR21HD094566 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA, CHRISTMAN, KAREN L · 2018 to 2019
$426k
Impact of Aging on Structure and Function of Pelvic Floor MusclesR03AG050951 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ALPERIN, MARIANNA · 2016 to 2017
$233k
Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Aging R01HD092515Eunice Kennedy Shriver National Institute of Child Health and Human Development; National Institute of Aging R21HD094566NCATS NIH HHS UL1 TR001442NIA NIH HHS R03 AG050951NIBIB NIH HHS T32 EB005970NICHD NIH HHS K12 HD001259NICHD NIH HHS R01 HD092515NICHD NIH HHS R21 HD094566NIH HHS UL1TR001442
6 · The paper itself

Abstract

Pelvic floor disorders negatively impact millions of women worldwide. Although there is a strong epidemiological association with childbirth, the mechanisms leading to the dysfunction of the integral constituents of the female pelvic floor, including pelvic floor skeletal muscles, are not well understood. This is in part due to the constraints associated with directly probing these muscles, which are located deep in the pelvis. Thus, experimental models and non-invasive techniques are essential for advancing knowledge of various phenotypes of pelvic floor muscle injury and pathogenesis of muscle dysfunction, as well as developing minimally invasive approaches for the delivery of novel therapeutics. The most widely used animal model for pelvic floor disorders is the rat. However, the radiological anatomy of rat pelvic floor muscles has not been described. To remedy this gap, the current study provides the first detailed description of the female rat pelvic floor muscles' radiological appearance on MR and ultrasound images, validated by correlation with gross anatomy and histology. We also demonstrate that ultrasound guidance can be used to target rat pelvic floor muscles for possible interventional therapies.

Indexed as

Multimodal ImagingMuscle, SkeletalPelvic FloorAnimalsFemaleMagnetic Resonance ImagingModels, AnimalRatsUltrasonographyanatomymagnetic resonance imagingpelvic floor musclesratultrasound

Identifiers

PMID30740685
PMCPMC6422690
OpenAlexW2912323713

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.