ArticleEClinicalMedicine2018
Early Childhood Outcomes After Neonatal Encephalopathy in Uganda: A Cohort Study.
Article in EClinicalMedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Neonatal intracranial pathologies on ultrasound imaging in sub-Saharan Africa: a systematic review and meta-analysis.Pediatric research · 2025Pooled it
- Predictors of outcome following neonatal encephalopathy in low- and middle-income countries: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- Growth and neurodevelopmental outcomes of preterm and low birth weight infants in rural Kenya: a cross-sectional study.BMJ open · 2023Trial
- Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial.Archives of disease in childhood. Fetal and neonatal edition · 2022Trial
- Predictors of mortality and severity of hypoxic-ischemic encephalopathy among neonates with birth asphyxia at Jimma University Medical Center, Southwest Ethiopia: a retrospective cohort study.Maternal health, neonatology and perinatology · 2026Article
- Validation of neurodevelopmental assessments for early detection of high-risk infants in Zimbabwe: protocol for the Child Development Observation study (ChiDO study).BMJ paediatrics open · 2026Article
- A scoping review and modelling of predictors of an abnormal Thompson score in term neonates in low-resource settings.Scientific reports · 2025Article
- Retrospective characterization of seizure semiology and treatment using continuous video-EEG monitoring in neonatal encephalopathy in Uganda.Epileptic disorders : international epilepsy journal with videotape · 2025Article
- Predicting cerebral palsy and 18-month neurodevelopmental outcome in infants with presumed hypoxic ischaemic encephalopathy: role of general movements assessment and early neurological examination.Frontiers in pediatrics · 2025Article
- Factors associated with cerebral palsy among children in Hawassa University comprehensive specialized hospital: Case-control study.PloS one · 2025Article
- Neurological examination of healthy term infants at ages 6 and 10 weeks in Tshwane District.The South African journal of physiotherapy · 2024Article
- Article
- Neurodevelopmental Outcome at 6 Months Following Neonatal Resuscitation in Rural Tanzania.Children (Basel, Switzerland) · 2023Article
- High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study.International journal of environmental research and public health · 2023Article
- Genetic diagnosis of fetal microcephaly at a single tertiary center in China.Frontiers in genetics · 2023Article
- Outborn newborns drive birth asphyxia mortality rates-An 8 year analysis at a rural level two nursery in Uganda.PLOS global public health · 2023Article
- Factors associated with birth asphyxia among term singleton births at two referral hospitals in Northern Uganda: a cross sectional study.BMC pregnancy and childbirth · 2022Article
- Elevated serum IL-10 is associated with severity of neonatal encephalopathy and adverse early childhood outcomes.Pediatric research · 2022Article
- Neonatal Seizures-Perspective in Low-and Middle-Income Countries.Indian journal of pediatrics · 2022Review
- Neurological impairment and disability in children in rural Kenya.Developmental medicine and child neurology · 2022Article
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Authors and funding
17 authors at 10 institutions in 3 countries.
Funding
Abstract
backgroundNeonatal encephalopathy (NE) is a leading cause of global child mortality. Survivor outcomes in low-resource settings are poorly described. We present early childhood outcomes after NE in Uganda.
methodsWe conducted a prospective cohort study of term-born infants with NE (n = 210) and a comparison group of term non-encephalopathic (non-NE) infants (n = 409), assessing neurodevelopmental impairment (NDI) and growth at 27-30 months. Relationships between early clinical parameters and later outcomes were summarised using risk ratios (RR).
findingsMortality by 27-30 months was 40·3% after NE and 3·8% in non-NE infants. Impairment-free survival occurred in 41·6% after NE and 98·7% of non-NE infants. Amongst NE survivors, 29·3% had NDI including 19·0% with cerebral palsy (CP), commonly bilateral spastic CP (64%); 10·3% had global developmental delay (GDD) without CP. CP was frequently associated with childhood seizures, vision and hearing loss and mortality. NDI was commonly associated with undernutrition (44·1% Z-score < - 2) and microcephaly (32·4% Z-score < - 2). Motor function scores were reduced in NE survivors without CP/GDD compared to non-NE infants (median difference - 8·2 (95% confidence interval; - 13·0, - 3·7)). Neonatal clinical seizures (RR 4.1(2.0-8.7)), abnormalities on cranial ultrasound, (RR 7.0(3.8-16.3), nasogastric feeding at discharge (RR 3·6(2·1-6·1)), and small head circumference at one year (Z-score < - 2, RR 4·9(2·9-5·6)) increased the risk of NDI.
interpretationIn this sub-Saharan African population, death and neurodevelopmental disability after NE were common. CP was associated with sensorineural impairment, malnutrition, seizures and high mortality by 2 years. Early clinical parameters predicted impairment outcomes.
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