Evidence map›Paper›PMID 30740515›Full record

ArticleAIMS molecular science2017

Expedited isolation of natural product peptidyl-tRNA hydrolase inhibitors from a Pth1 affinity column.

Harkirat S Sethi, Jessica L Osier, Geordan L Burks, Jennifer F Lamar, Hana McFeeters, Robert L McFeeters

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIMS molecular science, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 96% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Harkirat S SethiDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
Jessica L OsierDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
Geordan L BurksDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
Jennifer F LamarDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
Hana McFeetersDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
Robert L McFeetersDepartment of Chemistry, University of Alabama in Huntsville, Huntsville, AL, USA.
University of Alabama in Huntsville · US

Funding

Advancing Pth1 as an Antibiotic Target and Early Stage Discovery of Pth1 InhibitorsR15GM119052 · NIGMS · UNIVERSITY OF ALABAMA IN HUNTSVILLE · PI MCFEETERS, ROBERT · 2016 to 2016
$418k
NIGMS NIH HHS R15 GM119052
6 · The paper itself

Abstract

New antibiotics and new antibiotic targets are needed to counter the development of bacterial drug resistance that threatens to return the human population to the pre-antibiotic era. Bacterial peptidyl-tRNA hydrolase (Pth1) is a promising new antibiotic target in the early stages of development. While inhibitory activity has been observed in a variety of natural products, bioactive fractionation has been a bottleneck for inhibitor isolation. To expedite the isolation of inhibitory compounds from complex mixtures, we constructed a Pth1 affinity column and used it to isolate inhibitory compounds from crude natural products. Recombinantly produced

Indexed as

antibioticantimicrobialbioactive fractionationnovel inhibitor isolationnovel targetpeptidyl-tRNA hydrolasePth1Salmonella typhimurium

Identifiers

PMID30740515
PMCPMC6368095
OpenAlexW2613270470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.