Evidence map›Paper›PMID 30740513›Full record

ArticleSmall methods2017

Monitoring Neutropenia for Cancer Patients at the Point of Care.

Hakan Inan, James L Kingsley, Mehmet O Ozen, Huseyin Cumhur Tekin, Christian R Hoerner, Yoriko Imae, Thomas J Metzner, Jordan S Preiss, Naside Gozde Durmus, Mehmet Ozsoz and 4 more

Open access · bronzeAbstract read
In one paragraph

Article in Small methods, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Microneedle Patch for In Situ Neutrophil Monitoring.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  2. Hypogammaglobulinemia, late-onset neutropenia, and infections following rituximab.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2023
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 2 countries.

Hakan InanDemirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Stanford University School of Medicine.
James L KingsleyDepartment of Physics, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609-2280, USA.
Mehmet O OzenDemirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Stanford University School of Medicine.
Huseyin Cumhur TekinDepartment of Bioengineering, Izmir Institute of Technology, 35100 Urla, Izmir, Turkey.
Christian R HoernerDepartment of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Yoriko ImaeStanford Cancer Institute, Stanford, CA 94305, USA.
Thomas J MetznerStanford Cancer Institute, Stanford, CA 94305, USA.
Jordan S PreissStanford Cancer Institute, Stanford, CA 94305, USA.
Naside Gozde DurmusDepartment of Biochemistry, Stanford University, CA 94305, USA.
Mehmet OzsozIndependent Scholar, 35100, 6500/1 Sokak, No:8F, Karsiyaka/Izmir, Turkey.
Heather WakeleeDepartment of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Alice C FanDepartment of Medicine, Division of Oncology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Erkan TüzelDepartment of Physics, Worcester Polytechnic Institute, 100 Institute Road, Worcester, MA 01609-2280, USA.
Utkan DemirciDemirci Bio-Acoustic-MEMS in Medicine (BAMM) Laboratory, Stanford University School of Medicine.
Stanford University · USStanford Cancer InstituteWorcester Polytechnic Institute · USBluebird Bio (United States) · USCancer Prevention Institute of California · USIzmir Institute of Technology · TRKafkas University · TR

Funding

Rapid Fluorescence-Based Determination of Antibiotic SusceptibilityU54EB015408 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI PARRISH, JOHN A, SCHACHTER, STEVEN · 2012 to 2022
$49.2M
Nano Characterization and Nano Fabrication CoreU54CA199075 · NCI · STANFORD UNIVERSITY · PI GAMBHIR, SANJIV S · 2015 to 2019
$9.6M
Platform technology for detection of cancer-associated viruses in HIV patientsR01DE024971 · NIDCR · STANFORD UNIVERSITY · PI DEMIRCI, UTKAN, KAYE, KENNETH M · 2015 to 2019
$2.1M
NCI NIH HHS U54 CA199075NIBIB NIH HHS U54 EB015408NIDCR NIH HHS R01 DE024971
6 · The paper itself

Abstract

Neutrophils have a critical role in regulating the immune system. The immune system is compromised during chemotherapy, increasing infection risks and imposing a need for regular monitoring of neutrophil counts. Although commercial hematology analyzers are currently used in clinical practice for neutrophil counts, they are only available in clinics and hospitals, use large blood volumes, and are not available at the point of care (POC). Additionally, phlebotomy and blood processing require trained personnel, where patients are often admitted to hospitals when the infections are at late stage due to lack of frequent monitoring. Here, a reliable method is presented that selectively captures and quantifies white blood cells (WBCs) and neutrophils from a finger prick volume of whole blood by integrating microfluidics with high-resolution imaging algorithms. The platform is compact, portable, and easy to use. It captures and quantifies WBCs and neutrophils with high efficiency (>95%) and specificity (>95%) with an overall 4.2% bias compared to standard testing. The results from a small cohort of patients (

Indexed as

cancer monitoringlens-free shadow imagingmicrofluidicneutropenianeutrophilPoisson distribution

Identifiers

PMID30740513
PMCPMC6364993
OpenAlexW2743385001

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.