Evidence map›Paper›PMID 30740333›Full record

ArticleProcesses (Basel, Switzerland)2016

Algorithms for a Single Hormone Closed-Loop Artificial Pancreas: Challenges Pertinent to Chemical Process Operations and Control.

B Wayne Bequette, Faye Cameron, Nihat Baysal, Daniel P Howsmon, Bruce A Buckingham, David M Maahs, Carol J Levy

Open access · goldAbstract read
In one paragraph

Article in Processes (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

B Wayne BequetteDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180-3590, USA.
Faye CameronDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180-3590, USA.
Nihat BaysalDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180-3590, USA.
Daniel P HowsmonDepartment of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 Eighth St., Troy, NY 12180-3590, USA.
Bruce A BuckinghamStanford University, 780 Welch Road, CJ320H MC 5776, Palo Alto, CA 94304, USA.
David M MaahsStanford University, 780 Welch Road, CJ320H MC 5776, Palo Alto, CA 94304, USA.
Carol J LevyIcahn School of Medicine at Mt. Sinai, 1 Gustave A. Levy Place, New York, NY 10029, USA.
Rensselaer Polytechnic Institute · USIcahn School of Medicine at Mount Sinai · USStanford University · USUniversity of Colorado Denver · US

Funding

A probabilistic closed-loop artificial pancreas to handle unannounced meals R01DK102188 · NIDDK · RENSSELAER POLYTECHNIC INSTITUTE · PI BEQUETTE, B. WAYNE, BUCKINGHAM, BRUCE A · 2014 to 2016
$1.0M
NIDDK NIH HHS R01 DK102188
6 · The paper itself

Abstract

The development of a closed-loop artificial pancreas to regulate the blood glucose concentration of individuals with type 1 diabetes has been a focused area of research for over 50 years, with rapid progress during the past decade. The daily control challenges faced by someone with type 1 diabetes include asymmetric objectives and risks, and one-sided manipulated input action with frequent relatively fast disturbances. The major automation steps toward a closed-loop artificial pancreas include (i) monitoring and overnight alarms for hypoglycemia (low blood glucose); (ii) overnight low glucose suspend (LGS) systems to prevent hypoglycemia; and (iii) fully closed-loop systems that adjust insulin (and perhaps glucagon) to maintain desired blood glucose levels day and night. We focus on the steps that we used to develop and test a probabilistic, risk-based, model predictive control strategy for a fully closed-loop artificial pancreas. We complete the paper by discussing ramifications of lessons learned for chemical process systems applications.

Indexed as

artificial pancreasglucose controltype 1 diabetes

Identifiers

PMID30740333
PMCPMC6364834
OpenAlexW2539108574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.