Evidence map›Paper›PMID 30740306›Full record

ArticleMolecular genetics and metabolism reports2019

Feasibility of cellular bioenergetics as a biomarker in porphyria patients.

Balu Chacko, Matilda Lillian Culp, Joseph Bloomer, John Phillips, Yong-Fang Kuo, Victor Darley-Usmar, Ashwani K Singal

Open access · goldAbstract read
In one paragraph

Article in Molecular genetics and metabolism reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

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  12. Developmental regression and mitochondrial function in children with autism.Annals of clinical and translational neurology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Balu ChackoDepartment of Pathology and Mitochondrial Medicine Laboratory, University of Alabama at Birmingham, Birmingham, AL, United States.
Matilda Lillian CulpDepartment of Pathology and Mitochondrial Medicine Laboratory, University of Alabama at Birmingham, Birmingham, AL, United States.
Joseph BloomerDivision of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, United States.
John PhillipsDivision of Hematology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, United States.
Yong-Fang KuoDepartment of Preventive Medicine and Biostatistics, University of Texas Medical Branch, Galveston, TX 77555, United States.
Victor Darley-UsmarDepartment of Pathology and Mitochondrial Medicine Laboratory, University of Alabama at Birmingham, Birmingham, AL, United States.
Ashwani K SingalDivision of Gastroenterology and Hepatology, University of Alabama at Birmingham, Birmingham, AL, United States.
University of Alabama at Birmingham · USMitochondria Research and Medicine Society · USThe University of Texas Medical Branch at Galveston · USUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Porphyria is a group of metabolic disorders due to altered enzyme activities within the heme biosynthetic pathway. It is a systemic disease with multiple potential contributions to mitochondrial dysfunction and oxidative stress. Recently, it has become possible to measure mitochondrial function from cells isolated from peripheral blood (cellular bioenergetics) using the XF96 analyzer (

Indexed as

AHPAIPMitochondrialPCTProtoporphyria

Identifiers

PMID30740306
PMCPMC6355507
OpenAlexW2912955494

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.