ArticleJournal of bone oncology2019
Bone metastasis pattern of cancer patients with bone metastasis but no visceral metastasis.
Article in Journal of bone oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 34 citations in OpenAlex.
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- Diffuse midline glioma with extra central nervous system metastases in the pediatric, adolescent, and young adult population.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025Article
- Breast Cancer With Airway Edema Caused by Metastatic Fracture of the Cervical Vertebra.World journal of oncology · 2025Article
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- The emerging role of osteoclasts in the treatment of bone metastases: rationale and recent clinical evidence.Frontiers in oncology · 2024Review
- Long bone shaft metastasis: a comparative study between cement filling and intercalary prosthesis.World journal of surgical oncology · 2023Article
- Palliative Arterial Embolization for Metastases of the Sternum.Cardiovascular and interventional radiology · 2023Article
- What's new in the management of metastatic bone disease.European journal of orthopaedic surgery & traumatology : orthopedie traumatologie · 2021Review
- A predictive biomarker panel for bone metastases: Liquid biopsy approach.Journal of bone oncology · 2021Article
- Cancer of Unknown Primary Presenting as Bone-Predominant or Lymph Node-Only Disease: A Clinicopathologic Portrait.The oncologist · 2021Article
- Features of Spinal Metastases: A Retrospective View.International journal of spine surgery · 2021Article
- Comparison of the Relative Diagnostic Performance of [Frontiers in oncology · 2021Article
- Sentinel node theory helps tracking of primary lesions of cancers of unknown primary.BMC cancer · 2020Article
- Article
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Authors and funding
17 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBone metastasis of cancer can be a result from systemic blood spreading or vertebral venous plexus spreading. Systemic blood pathway induced bone metastasis can happen in any bone in the body since the spreading is considered to be random. However, it remains unknown whether there is any pattern of vertebral venous plexus related bone metastasis. In this study, we explored bone metastasis patterns in patients whose primary tumors had been well identified.
methodsWe included 290 consecutive cancer patients with bone metastases but no visceral metastases, out of 2559 patients whose bone metastases were diagnosed by positron emission tomography/computed tomography, between Jan 2015 and Oct 2017 at the Fudan University Shanghai Cancer Center. We excluded those with visceral metastasis to ensure that our study focused on metastasis through the vertebral venous plexus. And we analyzed the distribution and pattern of skeletal metastases.
resultsOf the 290 patients, 28 had head and neck tumors, 178 had thorax tumors, 49 had abdominal tumors and 35 had pelvic tumors; 102 (35%) had only one bone containing a metastasis and 188 (65%) had multiple bones containing metastases. Overall, metastases to the thoracic skeleton were more common in patients with thorax tumors than in other patients (81% vs. 67%,
conclusionsIn patients with only one bone containing a metastasis but no visceral metastasis, bones near the primary were more likely to be first metastasized. This may be a valuable clue to primary tumor sites in patients with cancers of unknown primaries.
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