Evidence map›Paper›PMID 30740294›Full record

ArticleCurrent transplantation reports2018

Immunosuppression for Lung Transplantation: Current and Future.

Satish Chandrashekaran, Stacy A Crow Pharm, Sadia Z Shah, Chris J Arendt Pharm, Cassie C Kennedy

Abstract read
In one paragraph

Article in Current transplantation reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. CD94The European respiratory journal · 2024
    Article
  4. Article
  5. Current perspective of immunomodulators for lung transplant.Indian journal of thoracic and cardiovascular surgery · 2022
    Review
  6. Article
  7. Review
  8. Observational
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Satish ChandrashekaranDivision of Pulmonary, Critical Care and Sleep Medicine, Lung Transplantation Program, University of Florida Gainesville, FL.
Stacy A Crow PharmPharmacy Services, Mayo Clinic, Rochester, MN.
Sadia Z ShahDivision of Pulmonary and Critical Care Medicine, Mayo Arizona.
Chris J Arendt PharmPharmacy Services, Mayo Clinic, Rochester, MN.
Cassie C KennedyWilliam J. von Liebig Center for Transplantation and Clinical Regeneration, Mayo Clinic, Rochester, MN.
Mayo Clinic in Arizona · USMayo Clinic · USUniversity of Florida · US

Funding

Exploring the Unmeasured Risk and Treating the Untreated Prognostic Factor: Towards Candidate Optimization in Heart and Lung TransplantK23HL128859 · NHLBI · MAYO CLINIC ROCHESTER · PI KENNEDY, CASSIE COLLEEN · 2016 to 2020
$854k
NHLBI NIH HHS K23 HL128859
6 · The paper itself

Abstract

purpose of the reviewThe number of lung transplantations performed worldwide continues to increase. There is a growing need in these patients for more effective immunosuppressive medications with less toxicity. RECENT

findingsThis review article summarizes the recent studies and developments in lung transplant immunosuppression. Novel immunosuppressive medications and strategies used in other solid organ transplantations are being trialed in lung transplantation. This includes the use of co-stimulation blockers like belatacept and mTOR inhibitors like everolimus. Calcineurin sparing regimens have been described in an attempt to minimize nephrotoxicity. Assays to measure the bioactivity of immunosuppressive medications to determine the global immune competence, such as Immuknow assay and Gamma interferon response are gaining traction. SUMMARY: Immunosuppression in lung transplant is evolving with the development of newer drugs and promising strategies to optimize immunosuppression. Further studies with multicenter randomized trials are required to increase the strength of the evidence.

Indexed as

calcineurin-sparing regimensglobal immune competenceimmunosuppressionLung transplantation

Identifiers

PMID30740294
PMCPMC6366648
OpenAlexW2883001666

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.