Evidence map›Paper›PMID 30740226›Full record

ReviewJournal of materials chemistry. B2019

Hybrid lipid-nanoparticle complexes for biomedical applications.

Kevin M Vargas, Young-Seok Shon

Abstract readReview
In one paragraph

Review in Journal of materials chemistry. B, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Nanoparticles as an Encouraging Therapeutic Approach to Alzheimer's Disease.International journal of molecular sciences · 2025
    Review
  5. Developing a potent vaccine againstExpert reviews in molecular medicine · 2024
    Review
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  18. Article
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  20. Biomaterials forGut microbes
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Kevin M VargasDepartment of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA.
Young-Seok ShonDepartment of Chemistry & Biochemistry, California State University Long Beach, Long Beach, California 90840-9507, USA.

Funding

Synthesis of Gold Nanoparticle-Cored Dendrimers Linked with Fluorophores and AntiSC3GM089562 · NIGMS · CALIFORNIA STATE UNIVERSITY LONG BEACH · PI SHON, YOUNG · 2011 to 2019
$859k
NIGMS NIH HHS SC3 GM089562
6 · The paper itself

Abstract

Biomolecule-nanoparticle hybrids have proven to be one of most promising frontiers in biomedical research. In recent years, there has been an increased focus on the development of hybrid lipid-nanoparticle complexes (HLNCs) which inherit unique properties of both the inorganic nanoparticles and the lipid assemblies (i.e. liposomes, lipoproteins, solid lipid nanoparticles, and nanoemulsions) that comprise them. In combination of their component parts, HLNCs also gain new functionalities which are utilized for numerous biomedical applications (i.e. stimuli-triggered drug release, photothermal therapy, and bioimaging). The localization of nanoparticles within the lipid assemblies largely dictates the attributes and functionalities of the hybrid complexes and are classified as such: (i) liposomes with surface-bound nanoparticles, (ii) liposomes with bilayer-embedded nanoparticles, (iii) liposomes with core-encapsulated nanoparticles, (iv) lipid assemblies with hydrophobic core-encapsulated nanoparticles, and (v) lipid bilayer-coated nanoparticles. Herein, we review the properties of each hybrid and the rational design of HLNCs for biomedical applications as reported by recent investigations. Future directions in advancing and expanding the scope of HLNCs are also proposed.

Indexed as

BiomimeticsChitosanDoxycyclineDrug CarriersHumansHydrophobic and Hydrophilic InteractionsLipid BilayersLiposomesNanoparticlesChitosanDoxycyclineDrug CarriersLipid BilayersLiposomes

Identifiers

PMID30740226
PMCPMC6363351

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.