ArticleOpen access Macedonian journal of medical sciences2019
Correlation between Serum 25-Hydroxyvitamin D Levels with Keloid Severity.
Article in Open access Macedonian journal of medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Intralesional vitamin D versus triamcinolone acetonide for the treatment of keloids: a systematic review and meta-analysis of randomized controlled trials.Frontiers in medicine · 2026Pooled it
- Impact of Vitamin D Injection on Keloids and Hypertrophic Scars.Journal of cosmetic dermatology · 2025Trial
- Systemic Comorbidities of Keloid and Hypertrophic Scars: A Phenome-Wide Association Study in a Multiethnic U.S. Pediatric Cohort.American journal of clinical dermatology · 2026Article
- Unveiling the Link: The Potential Roles of Vitamin D in Keloid Pathophysiology.Experimental dermatology · 2025Review
- Article
- Keloids as a Spectrum of Auto-Inflammatory Fibrotic Disorders: Beyond the Conventional Wound-Healing Paradigm.Clinical, cosmetic and investigational dermatology · 2025Review
- Comparison of Intralesional Vitamin D with Intralesional Triamcinolone Acetonide in the Treatment of Keloids.World journal of plastic surgery · 2024Article
- Influence of vitamin D receptor polymorphism rs2228570 on pathological scarring.Experimental and therapeutic medicine · 2022Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundKeloids are dermal fibroproliferative tumours characterised by excessive deposition of extra cellular matrix components. The active form of vitamin D is known to inhibit the proliferation of keloid fibroblasts by inhibiting extracellular matrix production induced by transforming growth factor ß (TGF-β) and increasing matrix metalloproteinase (MMP) activity. Vitamin D derivatives are thought to be an early preventive treatment strategy for keloid.
aimTo determine the correlation between serum 25-hydroxyvitamin D level with keloid severity.
methodsThis is a cross-sectional analytic study involving 32 keloid patients. Keloid patients were diagnosed by history and clinical examinations. Then an assessment of the severity was conducted using the Vancouver Scar Scale (VSS). We conducted blood sampling and measurement of serum 25-hydroxyvitamin D level to the patients. This study has been approved by the Health Research Ethics Commission of the Faculty of Medicine, Universitas Sumatera Utara, H. Adam Malik General Hospital Medan.
resultsThere is negative correlation between serum 25-hydroxyvitamin D level with severity in keloid patients (p = 0.0001; r = -0.737). There is no significant correlation between serum 25-hydroxyvitamin D level with gender (p = 0.271), age (p = 0.201; r = -0.232), duration of keloid (p = 0.505; r = -0.122) and family history (p = 0.262).
conclusionLower level of plasma 25-hydroxyvitamin D, the severity of keloid became an increasingly heavy. There is no significant difference between serum 25-hydroxyvitamin D level with gender, age, duration of keloid and family history in keloid patients.
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