Evidence map›Paper›PMID 30740148›Full record

ArticleAnalytical methods : advancing methods and applications2019

Review: New insights into optimizing chemical and 3D surface structures of carbon electrodes for neurotransmitter detection.

Qun Cao, Pumidech Puthongkham, B Jill Venton

Abstract read
In one paragraph

Article in Analytical methods : advancing methods and applications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed.

  1. Review
  2. Review
  3. Editorial: Carbon microelectrodes for neurochemical sensing.Frontiers in bioengineering and biotechnology · 2026
    Article
  4. Pyrolyzed Parylene-N forACS electrochemistry · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Surface-Roughened Graphene Oxide Microfibers Enhance Electrochemical Reversibility.Langmuir : the ACS journal of surfaces and colloids · 2024
    Article
  11. Review
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Qun CaoDept. of Chemistry, University of Virginia, Charlottesville, VA 22901.
Pumidech PuthongkhamDept. of Chemistry, University of Virginia, Charlottesville, VA 22901.
B Jill VentonDept. of Chemistry, University of Virginia, Charlottesville, VA 22901.

Funding

Real-Time Measurements of Neurotransmission in Drosphilia melanogasterR01MH085159 · NIMH · UNIVERSITY OF VIRGINIA · PI B. JILL VENTON · 2009 to 2026
$5.9M
Tunable Carbon Electrodes for in vivo Neurotransmitter DetectionR01EB026497 · NIBIB · UNIVERSITY OF VIRGINIA · PI VENTON, B. JILL · 2018 to 2021
$1.4M
NIBIB NIH HHS R01 EB026497NIMH NIH HHS R01 MH085159
6 · The paper itself

Abstract

The carbon-fiber microelectrode has been used for decades as a neurotransmitter sensor. Recently, new strategies have been developed for making carbon electrodes, including using carbon nanomaterials or pyrolyzing photoresist etched by nanolithography or 3D printing. This review summarizes how chemical and 3D surface structures of new carbon electrodes are optimized for neurotransmitter detection. There are effects of the chemical structure that are advantageous and nanomaterials are used ranging from carbon nanotube (CNT) to graphene to nanodiamond. Functionalization of these materials promotes surface oxide groups that adsorb dopamine and dopants introduce defect sites good for electron transfer. Polymer coatings such as poly(3,4-ethylenedioxythiophene) (PEDOT) or Nafion also enhance the selectivity, particularly for dopamine over ascorbic acid. Changing the 3D surface structure of an electrode increases current by adding more surface area. If the surface structure has roughness or pores on the micron scale, the electrode also acts as a thin layer cell, momentarily trapping the analyte for redox cycling. Vertically-aligned CNTs as well as lithographically-made or 3D printed pillar arrays act as thin layer cells, producing more reversible cyclic voltammograms. A better understanding of how chemical and surface structure affects electrochemistry enables rational design of electrodes. New carbon electrodes are being tested

Identifiers

PMID30740148
PMCPMC6366673

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.