ArticleDiabetology & metabolic syndrome2019
Potential impact of the joint association of total bilirubin and gamma-glutamyltransferase with metabolic syndrome.
Article in Diabetology & metabolic syndrome, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Associations between serum total bilirubin levels and the prevalence of metabolic syndrome in elderly Chinese males.BMC geriatrics · 2026Article
- Bilirubin bioconversion to urobilin in the gut-liver-kidney axis: A biomarker for insulin resistance in the Cardiovascular-Kidney-Metabolic (CKM) Syndrome.Metabolism: clinical and experimental · 2025Review
- Gut microbiota involvement in the effect of water-soluble dietary fiber on fatty liver and fibrosis.Bioscience of microbiota, food and health · 2025Article
- The association between bilirubin levels, and the incidence of metabolic syndrome and diabetes mellitus: a systematic review and meta-analysis of cohort studies.Clinical diabetes and endocrinology · 2024Review
- Gastrointestinal Dysfunction in Neurological and Neurodegenerative Disorders.Seminars in neurology · 2023Review
- Cross-sectional association between gamma-glutamyl transferase and hyperuricaemia: the China Multi-Ethinic Cohort (CMEC) study.BMJ open · 2022Article
- Gut microbiome is associated with metabolic syndrome accompanied by elevated gamma-glutamyl transpeptidase in men.Frontiers in cellular and infection microbiology · 2022Article
- The association of liver enzymes with diabetes mellitus risk in different obesity subgroups: A population-based study.Frontiers in endocrinology · 2022Article
- Non-uniformity of Changes in Drug-Metabolizing Enzymes and Transporters in Liver Cirrhosis: Implications for Drug Dosage Adjustment.Molecular pharmaceutics · 2021Article
- Age-Specific Association Between Body Mass Index and the Incidence of Atrial Fibrillation in Japanese Men.Circulation reports · 2020Article
- Association of total bilirubin and indirect bilirubin content with metabolic syndrome among Kazakhs in Xinjiang.BMC endocrine disorders · 2020Article
- Serum GGT and serum ferritin as early markers for metabolic syndrome.Journal of family medicine and primary care · 2020Article
- Serum total bilirubin is a risk factor of metabolic syndrome and its components in obese Egyptians.Porto biomedical journalArticle
- THE EFFECTS OF REALSIL (SILYBIN-PHOSPHOLIPID-VITAMIN E COMPLEX) ON LIVER ENZYMES IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD) OR NON-ALCOHOLIC STEATO-HEPATITIS (NASH): A SYSTEMATIC REVIEW AND META-ANALYSIS OF RCTS.Acta endocrinologica (Bucharest, Romania : 2005)Review
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMetabolic syndrome is characterized by the clustering of different metabolic abnormalities. Total bilirubin and gamma-glutamyltransferase (GGT) levels have been reported to be associated with this condition. However, the extent to which the interaction between these parameters affects metabolic syndrome is unknown. Therefore, we examined the association of total bilirubin and GGT levels with metabolic syndrome, and investigated the combined effect of the two parameters.
methodsIn this retrospective cohort study, we analyzed 8992 middle-aged Japanese subjects (4586 men, 4406 women; mean age, 44.8 ± 9.3 years) without metabolic syndrome from a cohort of employees undergoing annual health examinations. They were divided into four groups according to median total bilirubin and GGT levels: both-low, GGT-high, total bilirubin-high, and both-high. The incident of metabolic syndrome was evaluated during a follow-up of 2.8 ± 1.2 years.
resultsThe incident rate of metabolic syndrome during the follow-up was 4.6% in the both-low group, 12.1% in the GGT-high group, 2.7% in the total bilirubin-high group, and 10.6% in the both-high group. Total bilirubin and GGT have an interaction effect on the risk of incident metabolic syndrome (
conclusionsThe simultaneous presence of high total bilirubin and low GGT levels may be associated with a lower incidence of metabolic syndrome.
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