Evidence map›Paper›PMID 30740127›Full record

ArticleFrontiers in genetics2018

Homozygous Recessive Versican Missense Variation Is Associated With Early Teeth Loss in a Pakistani Family.

Stefania Bigoni, Marcella Neri, Chiara Scotton, Roberto Farina, Patrizia Sabatelli, Chongyi Jiang, Jianguo Zhang, Maria Sofia Falzarano, Rachele Rossi, Davide Ognibene and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 5 countries.

Stefania BigoniMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Marcella NeriMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Chiara ScottonMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Roberto FarinaResearch Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Ferrara, Italy.
Patrizia SabatelliInstitute of Molecular Genetics, National Research Council of Italy, Bologna, Italy.
Chongyi JiangBGI-Shenzhen, Shenzhen, China.
Jianguo ZhangBGI-Shenzhen, Shenzhen, China.
Maria Sofia FalzaranoMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Rachele RossiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Davide OgnibeneMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Rita SelvaticiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Francesca GualandiMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
Dieter BosshardtDepartment of Periodontology and Department of Oral Surgery and Stomatology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Paolo PerriEye Clinic, Sant'Anna University Hospital, Ferrara, Italy.
Claudio CampaEye Clinic, Sant'Anna University Hospital, Ferrara, Italy.
Francesco BrancatiDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila Italy.
Marco SalvatoreNational Institute of Health, Rome, Italy.
Maria Chiara De StefanoNational Institute of Health, Rome, Italy.
Domenica TaruscioNational Institute of Health, Rome, Italy.
Leonardo TrombelliResearch Centre for the Study of Periodontal and Peri-Implant Diseases, University of Ferrara, Ferrara, Italy.
Mingyan FangBGI-Shenzhen, Shenzhen, China.
Alessandra FerliniMedical Genetics Unit, Department of Medical Sciences, University of Ferrara, Ferrara, Italy.
University of Ferrara · ITBGI Group (China) · CNIstituto Dermopatico dell'Immacolata · ITKarolinska Institutet · SENational Research Council · ITUniversity College London · GBUniversity of Bern · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Only a few genes involved in teeth development and morphology are known to be responsible for tooth abnormalities in Mendelian-inherited diseases. We studied an inbred family of Pakistani origin in which two first-cousin born brothers are affected by early tooth loss with peculiar teeth abnormalities characterized by the absence of cementum formation. Whole exome sequencing revealed a H2665L homozygous sequence variant in the

Indexed as

dental cementumhumanperiodontiumversicanWagner syndrome

Identifiers

PMID30740127
PMCPMC6357929
OpenAlexW2909351065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.