ArticleFrontiers in immunology2019
The
Open access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 50 citations in OpenAlex.
- Pharmacological targeting of the JAK-STAT pathway: new concepts and emerging indications.Nature reviews. Drug discovery · 2026Review
- Heritability and Transcriptional Impact of JAK3, STAT5A and STAT6 Variants in a Tyrolean Family.International journal of molecular sciences · 2026Article
- Rethinking TYK2 P1104A: a flawed evolutionary trade-off in tuberculosis?Frontiers in immunology · 2026Review
- Investigation of the transcriptional impact of rare germline JAK/STAT variants found in a Tyrolean alpine community.BMC genomics · 2025Article
- Incomplete penetrance in inborn errors of immunity: A skeleton in the closet-The sequel.Journal of human immunity · 2025Review
- Genetic Susceptibility to Tuberculosis and the Utility of Polygenic Scores in Population Stratification.International journal of molecular sciences · 2025Review
- TYK2 inhibition enhances Treg differentiation and function while preventing Th1 and Th17 differentiation.Cell reports. Medicine · 2025Article
- TYK2 :p.Pro1104Ala Variant Protects Against Autoimmunity by Modulating Immune Cell Levels.Immunology · 2025Article
- Central TYK2 inhibition identifies TYK2 as a key neuroimmune modulator.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Cell-type-specific requirement for TYK2 in murine immune cells under steady state and challenged conditions.Cellular and molecular life sciences : CMLS · 2025Article
- TYK2 rs34536443 (P1104A) Variant Suppresses ICAM1-Mediated Inflammation: Insights From Mendelian Randomization and Functional Analyses.Psoriasis (Auckland, N.Z.) · 2025Article
- The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.Endocrine, metabolic & immune disorders drug targets · 2025Review
- Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet.Immunological reviews · 2024Review
- Sequential immunotherapy: towards cures for autoimmunity.Nature reviews. Drug discovery · 2024Review
- Tyrosine kinase 2 modulates splenic B cells through type I IFN and TLR7 signaling.Cellular and molecular life sciences : CMLS · 2024Article
- Article
- Nonclinical evaluations of deucravacitinib and Janus kinase inhibitors in homeostatic and inflammatory pathways.Frontiers in immunology · 2024Article
- Identifying pathogenic variants related to systemic lupus erythematosus by integrating genomic databases and a bioinformatic approach.Genomics & informatics · 2023Article
- Janus kinase inhibitors in systemic lupus erythematosus: implications for tyrosine kinase 2 inhibition.Frontiers in medicine · 2023Review
- Investigating the shared genetic architecture between hypothyroidism and rheumatoid arthritis.Frontiers in immunology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Jacquelyn A GormanCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Christian HundhausenTranslational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Mackenzie KinsmanTranslational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Tanvi ArkatkarCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Eric J AllenspachCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Courtnee CloughCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Samuel E WestCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Kerri ThomasCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Ahmet EkenCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Socheath KhimCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Malika HaleCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Mohamed OukkaCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Shaun W JacksonCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
Karen CerosalettiTranslational Research Program, Benaroya Research Institute, Seattle, WA, United States.
Jane H BucknerTranslational Research Program, Benaroya Research Institute, Seattle, WA, United States.
David J RawlingsCenter for Immunity and Immunotherapies, Seattle Children's Research Institute, Seattle, WA, United States.
University of Washington · USBenaroya Research Institute
Funding
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Tomas Vaisar · 1986 to 2026
$41.4MUniversity of Washington Medical Scientist Training Program: MD/PhDT32GM007266 · NIGMS · UNIVERSITY OF WASHINGTON · PI HORWITZ, MARSHALL S. · 1985 to 2023
$30.4MRESEARCH TRAINING IN RHEUMATOLOGYT32AR007108 · NIAMS · UNIVERSITY OF WASHINGTON · PI Shaun Jackson, Tomas M Mustelin · 1986 to 2026
$6.6MAn integrated strategy to define the functional and synergistic impact of T1D causal variantsDP3DK111802 · NIDDK · SEATTLE CHILDREN'S HOSPITAL · PI RAWLINGS, DAVID J · 2016 to 2016
$4.4MDefining the functional impact of T1D genes in mouse and man: a unified strategyDP3DK097672 · NIDDK · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BUCKNER, JANE HOYT · 2012 to 2013
$4.4MB cell-intrinsic cytokine regulation and B cell-targeted therapies in murine lupuK08AI112993 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI JACKSON, SHAUN WILLIAM · 2014 to 2018
$910kRole of IL-15 and IL-23 in colitisR01AI133885 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI OUKKA, MOHAMED · 2017 to 2018
$727kNIAID NIH HHS K08 AI112993NIAID NIH HHS R01 AI133885NIAMS NIH HHS T32 AR007108NIDDK NIH HHS DP3 DK097672NIDDK NIH HHS DP3 DK111802NIDDK NIH HHS P30 DK017047NIGMS NIH HHS T32 GM007266
Abstract
TYK2 is a JAK family member that functions downstream of multiple cytokine receptors. Genome wide association studies have linked a SNP (rs34536443) within
Indexed as
AdultAnimalsAutoimmunityB-LymphocytesEncephalomyelitis, Autoimmune, ExperimentalFemaleGene Knock-In TechniquesHumansInterferon Type IInterleukin-12Interleukin-23Lupus Erythematosus, SystemicMaleMiceMice, Inbred BALB CMice, Inbred C57BLInterferon Type IInterleukin-12Interleukin-23Receptors, Interleukin-12TYK2 KinaseTYK2 protein, humanTyk2 protein, mouseautoimmunitygerminal centerIFNARIL-12IL-23lupusTfhTYK2
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.