ReviewFrontiers in immunology2019
Trained Innate Immunity of Fish Is a Viable Approach in Larval Aquaculture.
Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 69 citations in OpenAlex.
- Nanotechnology-Based Immunostimulants in Aquaculture: Mechanisms, Advances and Practical Applications.Veterinary medicine and science · 2026Review
- Functional Feeds as Immunostimulants for Aquaculture: A Molecular Perspective.Aquaculture nutrition · 2026Review
- Exploring the Properties and Application Potential of β-Glucan in Skin Care.Food science & nutrition · 2025Review
- Interwoven processes in fish development: microbial community succession and immune maturation.PeerJ · 2024Review
- Unveiling the multifaceted role of toll-like receptors in immunity of aquatic animals: pioneering strategies for disease management.Frontiers in immunology · 2024Review
- Identification and analysis of differentially expressed microRNAs in gibel carpFish and shellfish immunology reports · 2023Article
- Article
- Priming European Sea Bass Female Broodstock Improves the Antimicrobial Immunity of Their Offspring.Animals : an open access journal from MDPI · 2023Article
- Effect of Treating Eggs with Coenzyme Q10 (CoQ10) on Growth Variables, Histomorphometry, and Antioxidant Capacity in Red Tilapia (Animals : an open access journal from MDPI · 2022Article
- Effects of Chitosan-Coated Microdiet on Dietary Physical Properties, Growth Performance, Digestive Enzyme Activities, Antioxidant Capacity, and Inflammation Response of Large Yellow Croaker (Aquaculture nutrition · 2022Article
- Screening and Validation of p38 MAPK Involved in Ovarian Development ofFrontiers in veterinary science · 2022Article
- Trained Immunity as an Adaptive Branch of Innate Immunity.International journal of molecular sciences · 2021Review
- Analysis of the Productivity, Immunity, and Health Performance of Nile Tilapia (Animals : an open access journal from MDPI · 2021Article
- Epidermal Club Cells in Fishes: A Case for Ecoimmunological Analysis.International journal of molecular sciences · 2021Review
- Structure-Functional Activity Relationship of β-Glucans From the Perspective of Immunomodulation: A Mini-Review.Frontiers in immunology · 2020Review
- Innate Immunomodulation in Food Animals: Evidence for Trained Immunity?Frontiers in immunology · 2020Review
- Evidence of Trained Immunity in a Fish: Conserved Features in Carp Macrophages.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Recombinant DnaK Orally Administered Protects Axenic European Sea Bass Against Vibriosis.Frontiers in immunology · 2019Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The general understanding has been that only adaptive immunity is capable of immunological memory, but this concept has been challenged in recent years by studies showing that innate immune systems can mount resistance to reinfection-as the innate immune system can adapt its function following an insult. Innate immune training offers an attractive approach in intensive fish larval rearing, especially since the adaptive immune system is not fully developed. Trained innate immunity will potentially favor robust fish in terms of resistance to viral and bacterial diseases. So-called immunostimulants such as ß-glucans have for decades been used both in laboratories and in intensive fish aquaculture. Treatment of fish by ß-glucans (and by other substances with pathogen-associated molecular patterns) often induces activation of non-specific/innate immune mechanisms and induces higher disease resistance. The reported effects of e.g., ß-glucans fit nicely into the concept "trained innate immunity," but the research on fish does not yet include analysis of epigenetic changes that may be a prerequisite for long-lasting trained innate immunity. In this "perspective," we will discuss how in practical terms and based on prior knowledge one can introduce innate immune training in brood stock fish, and their offspring, and whether innate immune training by ß-glucans is a viable approach in larval aquaculture.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.