ArticleFrontiers in behavioral neuroscience2018
Loss of Environmental Enrichment Elicits Behavioral and Physiological Dysregulation in Female Rats.
Article in Frontiers in behavioral neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Effects of enrichment removal on cognitive judgement bias of mice: a comparison of two paradigms.Frontiers in veterinary science · 2026Article
- Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats.Physiology & behavior · 2025Article
- Environmental enrichment with nylon gnaw sticks introduces variation in Sprague Dawley rat immune and lower gastrointestinal parameters with differences between sexes.Animal microbiome · 2025Article
- Social and nonsocial environmental loss have differential effects on ventral hippocampus-dependent behavior and inhibitory synaptic markers in adult male mice.Learning & memory (Cold Spring Harbor, N.Y.) · 2024Article
- Effects of temporary access to environmental enrichment on measures of laboratory mouse welfare.Scientific reports · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.Neurobiology of stress · 2024Article
- Adolescent environmental enrichment induces social resilience and alters neural gene expression in a selectively bred rodent model with anxious phenotype.bioRxiv : the preprint server for biology · 2024Article
- Resource choice during ontogeny enhances both the short- and longer-term welfare of laying hen pullets.Scientific reports · 2024Article
- Molecular neurobiology of loss: a role for basolateral amygdala extracellular matrix.Molecular psychiatry · 2023Article
- The emotional impact of disrupted environmental contexts: Enrichment loss and coping profiles influence stress response recovery in Long-Evans rats.Journal of neuroendocrinology · 2022Article
- Providing Environmental Enrichment without Altering Behavior in Male and Female Wistar Rats (Journal of the American Association for Laboratory Animal Science : JAALAS · 2022Article
- Towards Modeling Anhedonia and Its Treatment in Zebrafish.The international journal of neuropsychopharmacology · 2022Article
- Long-lasting housing environment manipulation and acute loss of environmental enrichment impact BALB/c mice behaviour in multiple functional domains.The European journal of neuroscience · 2022Article
- Environmental enrichment prevents stress-induced epigenetic changes in the expression of glucocorticoid receptor and corticotrophin releasing hormone in the central nucleus of the amygdala to inhibit visceral hypersensitivity.Experimental neurology · 2021Article
- Hidden talents: Poly (I:C)-induced maternal immune activation improves mouse visual discrimination performance and reversal learning in a sex-dependent manner.Genes, brain, and behavior · 2021Article
- The combination of fluoxetine and environmental enrichment reduces postpartum stress-related behaviors through the oxytocinergic system and HPA axis in mice.Scientific reports · 2021Article
- Differential impact of stress and environmental enrichment on corticolimbic circuits.Pharmacology, biochemistry, and behavior · 2020Review
- Environmental enrichment prevents chronic stress-induced brain-gut axis dysfunction through a GR-mediated mechanism in the central nucleus of the amygdala.Neurogastroenterology and motility · 2020Article
- Environmental enrichment reduces food seeking and taking in rats: A review.Pharmacology, biochemistry, and behavior · 2020Review
- Environmental influences on placental programming and offspring outcomes following maternal immune activation.Brain, behavior, and immunity · 2020Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Chronic stress drives behavioral and physiological changes associated with numerous psychiatric disease states. In rodents, the vast majority of chronic stress models involve imposition of external stressors, whereas in humans stress is often driven by internal cues, commonly associated with a sense of loss. We previously exposed groups of rats to environmental enrichment (EE) for a protracted period (1 month), followed by removal of enrichment (ER), to induce an experience of loss in male rats. ER enhanced immobility in the forced swim test (FST), led to hypothalamic pituitary adrenal (HPA) axis hypoactivity, and caused hyperphagia relative to continuously enriched (EE), single-housed (Scon) and pair-housed (Pcon) groups, most of which were reversible by antidepressant treatment (Smith et al., 2017). Here, we have applied the same approach to study enrichment loss in female rats. Similar to the males, enrichment removal in females led to an increase in the time spent immobile in the FST and increased daytime food intake compared to the single and pair-housed controls. Unlike males, ER females showed decreased sucrose preference, and showed estrus cycle-dependent HPA axis hyperactivity to an acute restraint stress. The increase in passive coping (immobility), anhedonia-like behavior in the sucrose preference test and HPA axis dysregulation suggest that enrichment removal produces a loss phenotype in females that differs from that seen in males, which may be more pronounced in nature.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.