Evidence map›Paper›PMID 30740000›Full record

ArticleSensors and actuators. B, Chemical2016

Screen-printed electrode produced by printed-circuit board technology. Application to Cancer Biomarker Detection by means of plastic antibody as sensing material.

Felismina T C Moreira, M Judite M S Ferreira, José R T Puga, M Goreti F Sales

Open access · hybridAbstract read
In one paragraph

Article in Sensors and actuators. B, Chemical, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
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  7. Innovative Quantification of Critical Quality Attributes.Advances in experimental medicine and biology · 2023
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  15. Recent Progress of Biomarker Detection Sensors.Research (Washington, D.C.) · 2020
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Felismina T C MoreiraBioMark-CINTESIS/ISEP, School of Engineering, Polytechnic Institute of Porto, Portugal.
M Judite M S FerreiraTID-CINTESIS/ School of Engineering, Polytechnic Institute of Porto, Portugal.
José R T PugaTID-CINTESIS/ School of Engineering, Polytechnic Institute of Porto, Portugal.
M Goreti F SalesBioMark-CINTESIS/ISEP, School of Engineering, Polytechnic Institute of Porto, Portugal.
Centre for Health Technology and Services Research · PTPolytechnic Institute of Porto · PT

Funding

European Research Council 311086
6 · The paper itself

Abstract

This research work presents, for the first time, a screen-printed electrode (SPE) made on a PCB board with silver tracks (Ag) and a three electrode configuration (AgxO-working, AgxO-counter and Ag/AgxO-reference electrodes), following the same approach as printed-circuit boards (PCBs). This low cost and disposable device was tested for screening a cancer biomarker in point-of-care. The selected biomarker was carcinogenic embryonic antigen (CEA) protein, routinely used to follow-up the progression of specific cancer diseases. The biosensor was constructed by assembling a plastic antibody on the Ag-working electrode area, acting as the biorecognition element of the device. The protein molecules that were entrapped on the polymer and positioned at the outer surface of the polypyrrole (PPy) film were removed by protease action. The imprinting effect was tested by preparing non-imprinted (NPPy) material, including only PPy as biorecognition element. Infrared and Raman studies confirmed the surface modification of these electrodes. The ability of the sensing material to rebind CEA was measured by several electrochemical techniques: cyclic voltammetry (CV), impedance spectroscopy (EIS) and square wave voltammetry (SWV). The linear response ranged from 0.05 to 1.25

Indexed as

BiosensorCarcinogenic embryonic antigenElectropolymerizationMolecular ImprintingPrinted circuit boardScreen-printed electrodes

Identifiers

PMID30740000
PMCPMC6366552
OpenAlexW1854114594

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.