Evidence map›Paper›PMID 30739984›Full record

ArticleJournal of pharmacy & pharmacognosy research

A comparative pharmacokinetic and pharmacodynamic study of two novel Cuban PEGylated rHuEPO

Gledys Reynaldo, Leyanis Rodríguez, Roberto Menéndez, Joaquín Solazábal, Daniel Amaro, María de Los A Becquer, Yamila Colom, Haydee Gil, Juan C Polo, Gilberto Castañeda and 3 more

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PubMed Full text at PMC
In one paragraph

Article in Journal of pharmacy & pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 3 countries.

Gledys ReynaldoDepartment of Pharmacy, Institute of Pharmacy & Foods, University of Havana, 222 St. and 23 Av. La Coronela, La Lisa, 13600, Havana, Cuba.
Leyanis RodríguezDepartment of Pharmacy, Institute of Pharmacy & Foods, University of Havana, 222 St. and 23 Av. La Coronela, La Lisa, 13600, Havana, Cuba.
Roberto MenéndezCenter of Neurosciences of Cuba, 190 St between 25 and 27, Cubanacan, Playa, 11600, Havana, Cuba.
Joaquín SolazábalCenter of Molecular Immunology, 216 St. and 15 St. Atabey, Playa. 11600, Havana, Cuba.
Daniel AmaroCenter of Molecular Immunology, 216 St. and 15 St. Atabey, Playa. 11600, Havana, Cuba.
María de Los A BecquerCenter for Research and Biological Evaluation, Institute of Pharmacy & Foods, University of Havana, 222 St. and 23 Av. La Coronela, La Lisa, 13600, Havana, Cuba.
Yamila ColomNational Institute of Oncology and Radiobiology (INOR), 29 St. and F, Vedado, Plaza de la Revolución, 10400, Havana, Cuba.
Haydee GilNational Institute of Oncology and Radiobiology (INOR), 29 St. and F, Vedado, Plaza de la Revolución, 10400, Havana, Cuba.
Juan C PoloDepartment of Pharmacy, Institute of Pharmacy & Foods, University of Havana, 222 St. and 23 Av. La Coronela, La Lisa, 13600, Havana, Cuba.
Gilberto CastañedaDepartment of Pharmacology, CINVESTAV-IPN, Av. IPN N0. 2508, Col. San Pedro Zacatenco, 07360, Delegación Gustavo A Madero, Mexico City, Mexico.
Braulio Jiménez-VélezUniversity of Puerto Rico Medical Sciences Campus, Department of Biochemistry, School of Medicine, PO Box 365067, 00936-5067, San Juan, Puerto Rico.
Jorge DucongeUniversity of Puerto Rico Medical Sciences Campus, Department of Pharmaceutical Sciences, School of Pharmacy, PO Box 365067, 00936-5067, San Juan, Puerto Rico.
Eduardo M Fernández-SánchezDepartment of Pharmacy, Institute of Pharmacy & Foods, University of Havana, 222 St. and 23 Av. La Coronela, La Lisa, 13600, Havana, Cuba.
University of Havana · CUCenter of Molecular Immunology (Cuba) · CUInstituto de Oncología y Radiobiología · CUUniversity of Puerto Rico, Medical Sciences Campus · PRCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXCuban Neuroscience Center · CU

Funding

TRANSLATIONAL PROTEOMICS CENTERG12MD007600 · NIMHD · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI FERNANDEZ-REPOLLET, EMMA · 2012 to 2016
$11.0M
A Genomic Approach to Warfarin Dose Prescription in Admixed Caribbean Hispanics.SC1HL123911 · NHLBI · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI DUCONGE, JORGE · 2014 to 2017
$982k
NHLBI NIH HHS SC1 HL123911NIMHD NIH HHS G12 MD007600
6 · The paper itself

Abstract

contextThe recombinant human erythropoietin (rHuEPO) stimulates the erythropoiesis process. Because this glycoprotein has a short half-life, it needs to be administrated two to three times a week. One of the technics to solve this issue is the PEGgilation.

aimsTo evaluate the pharmacokinetics (PK) and pharmacodynamics of two new branched PEGylated erythropoietins (i.e., an asymmetric 32 kDa-PEG

methodsSerum concentrations of both PEGylated and non-PEGylated erythropoietins were measured at various time points in order to determine PK parameters using non-compartmental analysis approach. The reticulocyte (%), erythrocyte count and hemoglobin levels were ascertained in order to compare the effect of these molecules after administrating a single intravenous dose (10 μg/kg) of each product in male New Zealand rabbits.

resultsBoth branched PEGylated erythropoietin forms exhibited half-lives that were significantly longer than ior

conclusionsThe PEGylation strategy employed in this study is an effective method to modify the pharmacokinetics and pharmacodynamics of rHuEPO molecule achieving higher half-lives and, therefore, longer

Indexed as

erythropoietinnon-compartmental analysisPEGylated EPOpharmacodynamicspharmacokineticsreticulocytes

Identifiers

PMID30739984
PMCPMC6364991
OpenAlexW3021439711

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.