ArticleBiological psychiatry2019
Accelerated Aging of Functional Brain Networks Supporting Cognitive Function in Psychotic Disorders.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Accelerated aging in schizophrenia: integrating epigenetic clocks, telomere dynamics, senescence-associated secretory phenotype, and oxidative stress.European archives of psychiatry and clinical neuroscience · 2026Review
- Characterizing Interthalamic Adhesion Morphology in Schizophrenia: Associations With Aging, Neuropsychological Functioning, and Atypical Hippocampal Development.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2026Article
- Deficits in Emotional Face Processing Indexed by N170 Modulation in Chronic and in First Hospitalized Schizophrenia.Clinical EEG and neuroscience · 2026Article
- Resting-state functional connectivity correlates of brain structural aging in schizophrenia.European archives of psychiatry and clinical neuroscience · 2025Article
- Relations of temporoparietal connectivity with neighborhood social fragmentation in youth at clinical high-risk for psychosis.Schizophrenia research · 2025Article
- Reduced hippocampal volume unmasks distinct impacts of cumulative adverse childhood events (ACEs) on psychotic-like experiences in late childhood and early adolescence.Psychoneuroendocrinology · 2024Article
- The insula: Leveraging cellular and systems-level research to better understand its roles in health and schizophrenia.Neuroscience and biobehavioral reviews · 2024Review
- The Genomic Intersection of Oligodendrocyte Dynamics in Schizophrenia and Aging Unravels Novel Pathological Mechanisms and Therapeutic Potentials.International journal of molecular sciences · 2024Review
- Intrinsic functional connectivity correlates of cognitive deficits involving sustained attention and executive function in bipolar disorder.BMC psychiatry · 2023Article
- The distinct disrupted plasticity in structural and functional network in mild stroke with basal ganglia region infarcts.Brain imaging and behavior · 2022Article
- Age-dependent effects of schizophrenia genetic risk on cortical thickness and cortical surface area: Evaluating evidence for neurodevelopmental and neurodegenerative models of schizophrenia.Journal of psychopathology and clinical science · 2022Article
- Disentangling age- and disease-related alterations in schizophrenia brain network using structural equation modeling: A graph theoretical study based on minimum spanning tree.Human brain mapping · 2021Article
- Interactions Between Aging and Alzheimer's Disease on Structural Brain Networks.Frontiers in aging neuroscience · 2021Article
- What a Clinician Should Know About the Neurobiology of Schizophrenia: A Historical Perspective to Current Understanding.Focus (American Psychiatric Publishing) · 2020Article
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Authors and funding
5 authors.
Funding
Abstract
backgroundAcross networks, connectivity within the frontoparietal network (FPN) and cingulo-opercular network (CON) exhibits reductions earliest during healthy aging, contributing to cognitive impairment. Individuals with psychotic disorders demonstrate evidence of accelerated aging across multiple biological systems. By leveraging a large sample of patients with psychosis from early to chronic illness stages, this study sought to determine whether the CON and FPN exhibit evidence of accelerated aging in psychotic disorders, confirm associations between network efficiency and cognition, and determine whether reduced network efficiency is observed in early-stage psychosis.
methodsResting-state functional magnetic resonance imaging and cognitive data were obtained on 240 patients with psychotic disorder and 178 healthy control participants (HCs). Global efficiency, a measure of functional integration, was calculated for the CON, FPN, subcortical network, and visual network. Associations with age and cognition were assessed and compared between groups.
resultsConsistent with accelerated aging, significant group by age interactions reflected significantly stronger relationships between efficiency and age in patients with psychosis than in HCs for both the CON (psychosis: r = -.37; HC: r = -.16) and FPN (psychosis: r = -.31; HC: r = -.05). Accelerated aging was not observed in either the subcortical or visual network, suggesting specificity for cognitive networks that decline earliest in healthy aging. Replicating prior findings, efficiency of both the CON and FPN correlated with cognitive function across all participants (rs > .11, ps < .031). Furthermore, patients with chronic psychosis (p = .004), but not patients with early psychosis (p = .553), exhibited significantly lower FPN efficiency compared with HCs.
conclusionsFunctional integration of higher-order cognitive networks is intact in early psychosis but exhibits evidence of accelerated aging, suggesting the potential for intervention targeting cognition within the early psychosis period.
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