ArticleCell2019
Chronic Inflammation Permanently Reshapes Tissue-Resident Immunity in Celiac Disease.
Open access · bronzeAbstract read
In one paragraph
Article in Cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 1 pooled it
16.7field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
111 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.
- Circulating miRNAs as Potential Biomarkers for Celiac Disease Development.Frontiers in immunology · 2021Pooled it
- Phenotypic shift of small intestinal intra-epithelial type 1 innate lymphoid cells in celiac disease is associated with enhanced cytotoxic potential.Clinical and experimental immunology · 2020Trial
- GPR55 negatively regulates CD8Journal of molecular histology · 2026Article
- Evaluation of Novel Immunohistochemical Biomarkers for the Diagnosis of Celiac Disease Demonstrates the Utility of TCRδ Immunostaining.Diagnostics (Basel, Switzerland) · 2026Article
- The Role and Potential Mechanism of Pectin and Pectin Oligosaccharides in Treating Intestinal Inflammation by Regulating Gut Microbiota.Probiotics and antimicrobial proteins · 2026Review
- Evaluating the utility of amino acid similarity-aware kmers to represent TCR repertoires for classification.PLoS computational biology · 2026Article
- γδ T Cells in Autoinflammatory Diseases.Cells · 2026Review
- TCRγ constant usage tunes human γδ T cell antigen sensitivity, thymic programming, and peripheral function.Science immunology · 2026Article
- Single-cell profiling reveals diverse γδ T cell subsets in ulcerative colitis.Science immunology · 2026Article
- Innate immune dysregulation in celiac disease and refractory celiac disease: mechanisms, management and emerging therapies.Frontiers in immunology · 2026Review
- γδ T cells: bridging innate and adaptive immunity in development, tissue residency, and disease.Frontiers in immunology · 2026Review
- Functional heterogeneity of γδ T cells in colorectal cancer.Frontiers in immunology · 2026Review
- Evidence of an allostatic response by intestinal tissues following induction of joint inflammation.PloS one · 2026Article
- γδ T cell receptor recognition of CD1d in a lipid-independent manner.Nature communications · 2025Article
- Article
- IFN-γ is a direct driver of crypt hyperplasia in celiac disease.The Journal of clinical investigation · 2025Article
- Transcriptomics and eQTLs reveal inflammatory heterogeneity in the duodenal lining in coeliac disease.Genes and immunity · 2025Article
- Article
- Immune-epithelial-stromal networks define the cellular ecosystem of the small intestine in celiac disease.Nature immunology · 2025Article
- New therapies in celiac disease.Current opinion in gastroenterology · 2025Review
51 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 9 institutions in 5 countries.
Toufic MayassiCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA.
Kristin LadellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Herman GudjonsonInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA; Department of Chemistry, University of Chicago, Chicago, IL, USA.
James E McLarenDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK.
Dustin G ShawCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA.
Mai T TranInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Jagoda J RokickaDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Ian LawrenceDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Jean-Christophe GrenierDepartment of Genetics, CHU Sainte-Justine Research Center, Montreal, QC, Canada.
Vincent van UnenDepartment of Immunohematology and Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.
Cezary CiszewskiDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Matthew DimaanoDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Hoda E SayeghDepartment of Medicine, University of Chicago, Chicago, IL, USA.
Vinod KumarDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Cisca WijmengaDepartment of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Peter H R GreenCeliac Disease Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY, USA.
Ranjana GokhaleSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
Hilary JerichoSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
Carol E SemradDepartment of Medicine, University of Chicago, Chicago, IL, USA; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
Stefano GuandaliniSection of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA; University of Chicago Celiac Disease Center, University of Chicago, Chicago, IL, USA.
Aaron R DinnerInstitute for Biophysical Dynamics, University of Chicago, Chicago, IL, USA; Department of Chemistry, University of Chicago, Chicago, IL, USA; James Franck Institute, University of Chicago, Chicago, IL, USA.
Sonia S KupferDepartment of Medicine, University of Chicago, Chicago, IL, USA; Section of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Chicago, Chicago, IL, USA.
Hugh H ReidInfection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.
Luis B BarreiroDepartment of Genetics, CHU Sainte-Justine Research Center, Montreal, QC, Canada.
Jamie RossjohnDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK; Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC, Australia.
David A PriceDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, UK. Electronic address: priced6@cardiff.ac.uk.
Bana JabriCommittee on Immunology, University of Chicago, Chicago, IL, USA; Department of Medicine, University of Chicago, Chicago, IL, USA; Department of Pathology, University of Chicago, Chicago, IL, USA. Electronic address: bjabri@bsd.uchicago.edu.
University of Chicago · USCardiff University · GBCentre Hospitalier Universitaire Sainte-Justine · CAMonash University · AUAustralian Research Council · AUColumbia University Irving Medical Center · USLeiden University Medical Center · NLUniversity Medical Center Groningen · NLUniversity of Groningen · NL
Funding
MEDICAL SCIENTIST TRAININGT32GM007281 · NIGMS · UNIVERSITY OF CHICAGO · PI CLARK, MARCUS RAMSAY · 1985 to 2022
$32.1MULTRASTRUCTURE AND CYTOMORPHOLOGY COREP30DK042086 · NIDDK · UNIVERSITY OF CHICAGO · PI LIU, CAMBRIAN YANGSHAO · 1990 to 2025
$29.8MINTERDISCIPLINARY TRAINING PROGRAM IN IMMUNOLOGYT32AI007090 · NIAID · UNIVERSITY OF CHICAGO · PI Peter Aidan Savage · 1985 to 2026
$11.7MInnate and adaptive immunity in celiac diseaseR01DK067180 · NIDDK · UNIVERSITY OF CHICAGO · PI JABRI, BANA · 2005 to 2024
$8.5MAdaptive immunity in primary sclerosing cholangitis patients at risk for colorectal cancerF30DK121470 · NIDDK · UNIVERSITY OF CHICAGO · PI SHAW, DUSTIN · 2019 to 2022
$203kNIAID NIH HHS T32 AI007090NIDDK NIH HHS F30 DK121470NIDDK NIH HHS P30 DK042086NIDDK NIH HHS R01 DK067180NIGMS NIH HHS T32 GM007281Wellcome Trust 100326Z/12/Z
Abstract
Tissue-resident lymphocytes play a key role in immune surveillance, but it remains unclear how these inherently stable cell populations respond to chronic inflammation. In the setting of celiac disease (CeD), where exposure to dietary antigen can be controlled, gluten-induced inflammation triggered a profound depletion of naturally occurring Vγ4
Indexed as
AntigensButyrophilinsCeliac DiseaseChronic DiseaseDiet, Gluten-FreeGlutensHEK293 CellsHumansInflammationIntestinal MucosaIntraepithelial LymphocytesReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltaAntigensButyrophilinsGlutensReceptors, Antigen, T-CellReceptors, Antigen, T-Cell, gamma-deltabutyrophilin-like moleculesceliac diseaseintraepithelial lymphocytestissue-resident lymphocytesγδ T cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.