ArticleChest2019
Chronic Rhinosinusitis Is an Independent Risk Factor for OSA in World Trade Center Responders.
Article in Chest, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Investigation of relationship between occupational exposure to aerosol and sleep problems: A systematic review and meta-analysis.PloS one · 2025Pooled it
- Is exposure to chemical pollutants associated with sleep outcomes? A systematic review.Sleep medicine reviews · 2023Pooled it
- Prevalence of sleep disorders among first responders for medical emergencies: A meta-analysis.Journal of global health · 2022Pooled it
- PAP Adherence and Nasal Resistance. A Randomized Controlled Trial of CPAPflex versus CPAP in World Trade Center Responders.Annals of the American Thoracic Society · 2021Trial
- Temporal snoring metrics and obstructive sleep apnea severity: nonlinear associations and data-driven inflection points in a clinical cohort.Sleep & breathing = Schlaf & Atmung · 2026Article
- Impact of World Trade Center dust exposure on upper-aero digestive tract disorders and sinonasal surgery: findings from patients seen in the Department of Otolaryngology - Head and Neck Surgery at Mount Sinai Hospital.Occupational and environmental medicine · 2026Article
- Oxidative stress in patients with nasal respiratory impairment and OSAS.Sleep & breathing = Schlaf & Atmung · 2025Article
- Exposure to the World Trade Center Disaster, Health, and Health-Related Quality of Life Nearly 20 Years After 9/11.American journal of industrial medicine · 2025Article
- Obstructive sleep apnea and structural and functional brain alterations: a brain-wide investigation from clinical association to genetic causality.BMC medicine · 2025Article
- Associations Between Occupational Exposures to Volatile Organic Compounds (VOCs) and Sleep Problems.Public health reviews · 2025Review
- Current Review of Comorbidities in Chronic Rhinosinusitis.Current allergy and asthma reports · 2024Review
- Nasal resistance and inflammation: mechanisms for obstructive sleep apnea from chronic rhinosinusitis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Relationship between chronic rhinosinusitis and risk of obstructive sleep apnea.Scientific reports · 2024Article
- Lack of association of impaired upper airway sensation with the presence or absence of obstructive sleep apnoea or chronic rhinosinusitis in World Trade Center responders.Occupational and environmental medicine · 2024Article
- Reply to GanAmerican journal of respiratory and critical care medicine · 2024Article
- Psychiatric Burden in Chronic Sinonasal Diseases: A Single-Center Cross-Sectional Observational Study.Cureus · 2024Article
- Airways Type-2 Related Disorders: Multiorgan, Systemic or Syndemic Disease?International journal of molecular sciences · 2024Review
- Treatable Traits in Pregnant Women with Asthma.Respiration; international review of thoracic diseases · 2024Review
- Advancements in Home-Based Devices for Detecting Obstructive Sleep Apnea: A Comprehensive Study.Sensors (Basel, Switzerland) · 2023Review
- Risk of new-onset and prevalent disease in chronic rhinosinusitis: A prospective cohort study.International forum of allergy & rhinology · 2023Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundMany respiratory conditions have been attributed to toxic dust and fume exposure in World Trade Center (WTC) rescue and recovery workers, who frequently report symptoms of OSA. We examined the prevalence of new-onset OSA and tested if the prevalence and severity of OSA are related to the presence of chronic rhinosinusitis (CRS).
methodsA total of 601 subjects (83% men; age, 33-87 years; BMI, 29.9 ± 5.5 kg/m
resultsThe prevalence of OSA was 75% (25% no OSA, 46% mild OSA, 19% moderate OSA, and 10% severe OSA), and the prevalence of CRS was 43.5%. Compared with no CRS, new and worsening CRS was a significant risk factor for OSA with an OR of 1.80 (95% CI, 1.18-2.73; P = .006) unadjusted and 1.76 (95% CI, 1.08-2.88; P = .02) after adjustment for age, BMI, sex, gastroesophageal reflux disorder, and alcohol use.
conclusionsThe high prevalence of OSA in WTC responders was not explained fully by obesity and sex. Possible mechanisms for the elevated risk of OSA in subjects with CRS include increased upper airway inflammation and/or elevated nasal/upper airway resistance, but these need confirmation.
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