Evidence map›Paper›PMID 30739537›Full record

ArticleHypertension (Dallas, Tex. : 1979)2019

Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II-Induced Microvascular Dysfunction.

Elena Y Senchenkova, Janice Russell, Alper Yildirim, D Neil Granger, Felicity N E Gavins

Erratum issuedOpen access · greenAbstract read
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 86 citations in OpenAlex.

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  13. Validity of mental and physical stress models.Neuroscience and biobehavioral reviews · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Elena Y SenchenkovaFrom the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).
Janice RussellFrom the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).
Alper YildirimFrom the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).
D Neil GrangerFrom the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).
Felicity N E GavinsFrom the Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center-Shreveport, Shreveport (E.Y.S., J.R., A.Y., D.N.G., F.N.E.G.).
Louisiana State University Health Sciences Center Shreveport · US

Funding

Investigating the dysfunction of the cerebral microvasculature in sickle cell diseaseR01HL134959 · NHLBI · LOUISIANA STATE UNIV HSC SHREVEPORT · PI STOKES, KAREN Y · 2017 to 2020
$1.4M
NHLBI NIH HHS R01 HL134959
6 · The paper itself

Abstract

Hypertension is an established risk factor for subsequent cardiovascular diseases, with Ang II (angiotensin II) playing a major role in mediating thrombotic and inflammatory abnormalities. Although T cells and IL-6 (interleukin-6) play an important role in adaptive immune responses, little is known about their role(s) in the thromboinflammatory responses associated with Ang II. Here we show using intravital microscopy coupled with the light/dye injury model that Rag-1 deficient (Rag-1

Indexed as

Adaptive ImmunityAngiotensin IIAnimalsBlood PressureDisease Models, AnimalFlow CytometryHypertensionInterleukin-6MaleMiceMice, Inbred C57BLMice, KnockoutMicrocirculationSignal TransductionThrombosisT-LymphocytesAngiotensin IIInterleukin-6angiotensin IIhypertensioninflammationinterleukin-6thrombosis

Identifiers

PMID30739537
PMCPMC6422352
OpenAlexW2914777921

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.