Evidence map›Paper›PMID 30739533›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2019

Enzymatic analysis of glucuronidation of synthetic cannabinoid 1-naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22).

Sabrina Jones, Azure L Yarbrough, Amal Shoeib, John M Bush, William E Fantegrossi, Paul L Prather, Anna Radominska-Pandya, Ryoichi Fujiwara

Open access · greenAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Sabrina JonesDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Azure L YarbroughDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Amal ShoeibDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
John M BushDepartment of Biology, University of Arkansas Little Rock , Little Rock , AR , USA.
William E FantegrossiDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Paul L PratherDepartment of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Anna Radominska-PandyaDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
Ryoichi FujiwaraDepartment of Biochemistry and Molecular Biology, College of Medicine, University of Arkansas for Medical Sciences , Little Rock , AR , USA.
University of Arkansas for Medical Sciences · USUniversity of Arkansas at Little Rock · USUniversity of Arkansas at Fayetteville · US

Funding

Synthetic Cannabinoid Toxicity: Role of BiotransformationR01DA039143 · NIDA · UNIV OF ARKANSAS FOR MED SCIS · PI PRATHER, PAUL L · 2016 to 2020
$2.9M
NIDA NIH HHS R01 DA039143
6 · The paper itself

Abstract

Recently, there has been a rise in abuse of synthetic cannabinoids (SCBs). The consumption of SCBs results in various effects and can induce toxic reactions, including paranoia, seizures, tachycardia and even death. 1-Naphthyl 1-(4-fluorobenzyl)-1H-indole-3-carboxylate (FDU-PB-22) is a third generation SCB whose metabolic pathway has not been fully characterized. In this study, we conducted

Indexed as

CannabinoidsEnzyme InhibitorsGlucuronosyltransferaseHumansIllicit DrugsInactivation, MetabolicIndolesMicrosomes, LiverRecombinant ProteinsUridine Diphosphate Glucuronic AcidCannabinoidsEnzyme InhibitorsFDU-PB-22GlucuronosyltransferaseIllicit DrugsIndolesRecombinant ProteinsUridine Diphosphate Glucuronic AcidFBI-COOHFDU-PB-22Glucuronidationkinetic analysissynthetic cannabinoids

Identifiers

PMID30739533
PMCPMC7133092
OpenAlexW2911902764

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.