Evidence map›Paper›PMID 30739530›Full record

ArticleCell cycle (Georgetown, Tex.)2019

ARPE-19-derived VEGF-containing exosomes promote neovascularization in HUVEC: the role of the melanocortin receptor 5.

Rosa Maisto, María Oltra, Lorena Vidal-Gil, Natalia Martínez-Gil, Javier Sancho-Pellúz, Clara Di Filippo, Settimio Rossi, Michele D Amico, Jorge Miguel Barcia, Francisco Javier Romero

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.2field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Rosa Maistoa Department of Experimental Medicine , Università degli studi della Campania Luigi Vanvitelli , Napoli , Italy.
María Oltrab Neurobiología y Neurofisiología, Facultad de Medicina , Universidad Católica de Valencia "San Vicente Mártir" , Valencia , Spain.
Lorena Vidal-Gilb Neurobiología y Neurofisiología, Facultad de Medicina , Universidad Católica de Valencia "San Vicente Mártir" , Valencia , Spain.
Natalia Martínez-Gilc Department of Basic Medical Sciences , Universidad Europea de Valencia , Valencia , Spain.
Javier Sancho-Pellúzb Neurobiología y Neurofisiología, Facultad de Medicina , Universidad Católica de Valencia "San Vicente Mártir" , Valencia , Spain.ORCID 0000-0001-5409-5760
Clara Di Filippoa Department of Experimental Medicine , Università degli studi della Campania Luigi Vanvitelli , Napoli , Italy.
Settimio Rossia Department of Experimental Medicine , Università degli studi della Campania Luigi Vanvitelli , Napoli , Italy.
Michele D Amicoa Department of Experimental Medicine , Università degli studi della Campania Luigi Vanvitelli , Napoli , Italy.
Jorge Miguel Barciab Neurobiología y Neurofisiología, Facultad de Medicina , Universidad Católica de Valencia "San Vicente Mártir" , Valencia , Spain.ORCID 0000-0002-3660-7977
Francisco Javier Romeroc Department of Basic Medical Sciences , Universidad Europea de Valencia , Valencia , Spain.ORCID 0000-0001-8701-5907
Valencia Catholic University Saint Vincent Martyr · ESUniversidad Europea de Madrid · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

ARPE-19 retinal pigment epithelial cells cultured in a medium containing 35 mM D-glucose led to an augmented ROS formation and release of vascular endothelial factor (VEGF)-containing exosomes compared to ARPE-19 cells cultured in a medium containing 5 mM D-glucose (standard medium). Exposing these cells to the melanocortin 5 receptor agonist (MCR

Indexed as

alpha-MSHCell LineCell SurvivalCulture MediaCytochrome P-450 CYP2E1ExosomesGlucoseHumansHuman Umbilical Vein Endothelial CellsImidazolesNeovascularization, PhysiologicNF-kappa BPeptides, CyclicReactive Oxygen SpeciesReceptor, Melanocortin, Type 1Receptor, Melanocortin, Type 3acetyl-norleucyl(4)-(aspartyl(5)-histidyl(6)-phenylalanyl(7)-arginyl(8)-tryptophyl(9)-lysyl(10))cyclo-alpha-MSH(4-10)amidealpha-MSHBMS-470539Culture MediaCytochrome P-450 CYP2E1GlucoseImidazolesMC1R protein, humanMC3R protein, humanmelanocortin 5 receptorNF-kappa BPeptides, CyclicPG 901Reactive Oxygen SpeciesReceptor, Melanocortin, Type 1Receptor, Melanocortin, Type 3Receptors, MelanocortinVascular Endothelial Growth Factor AVEGFA protein, humanDiabetesexosomesmelanocortin receptorsoxidative stressvasculogenesis

Identifiers

PMID30739530
PMCPMC6422460
OpenAlexW2912876155

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.