Evidence map›Paper›PMID 30739188›Full record

SynthesisEuropean spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society2019

Antifibrinolytic agents for paediatric scoliosis surgery: a systematic review and meta-analysis.

Shoahaib Karimi, Victor M Lu, Mithun Nambiar, Kevin Phan, Anuruthran Ambikaipalan, Ralph J Mobbs

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Efficacy and Safety of Tranexamic Acid in Pediatric Trauma: A Systematic Review and Meta-Analysis.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026
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  4. Article
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Shoahaib KarimiFaculty of Medicine, Melbourne School of Medicine, Melbourne University, Melbourne, VIC, Australia. shoahaibkarimi@gmail.com.ORCID http://orcid.org/0000-0003-1802-1873
Victor M LuFaculty of Medicine, University of Sydney, Sydney, NSW, Australia.
Mithun NambiarDepartment of Surgery, The University of Melbourne, Melbourne, VIC, Australia.
Kevin PhanFaculty of Medicine, University of Sydney, Sydney, NSW, Australia.
Anuruthran AmbikaipalanDepartment of Orthopaedic Surgery, Box Hill Hospital, Melbourne, Australia.
Ralph J MobbsNeuroSpine Surgery Research Group, Prince of Wales Private Hospital, Randwick, Sydney, NSW, Australia.
Box Hill Hospital · AUThe University of Sydney · AUPrince of Wales Hospital · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designSystematic review and meta-analysis of randomised controlled trials.

objectiveThe purpose of this study is to perform a systematic review and meta-analysis of antifibrinolytic agents for paediatric spine surgery.

backgroundBleeding is an important consideration in paediatric scoliosis surgery; blood loss leads directly to higher morbidity and mortality. Antifibrinolytics are an attractive non-invasive method of reducing bleeding as evidenced in arthroplasty, cardiac surgery and adult scoliosis surgery.

methodsA thorough database search of Medline, PubMed, EMBASE and Cochrane was performed according to PRISMA guidelines, and a systematic review was performed.

resultsFive randomised controlled trials were identified in this meta-analysis, consisting of a total of 285 spine surgery patients with subgroups of tranexamic acid (n = 101), epsilon aminocaproic acid (n = 61) and control (n = 123). This meta-analysis found that antifibrinolytics lead to statistically significant reductions in peri-operative blood loss (MD - 379.16, 95% CI [- 579.76, - 178.57], p < 0.001), intra-operative blood loss (MD - 516.42, 95% CI [- 1055.58, 22.74], p < 0.001), reduced fresh frozen plasma requirements (MD - 307.77, 95% CI [- 369.66, - 245.88], p < 0.001) and reduced post-operative blood loss (MD -  185.95, 95% CI [- 336.04, - 35.87], p = 0.02).

conclusionThis meta-analysis concludes that antifibrinolytics lead to statistically significant reductions in peri-operative blood loss, intra-operative blood loss, reduced fresh frozen plasma requirements and reduced post-operative blood loss with TXA. These slides can be retrieved under Electronic Supplementary Material.

Indexed as

Blood Loss, SurgicalPostoperative HemorrhageAntifibrinolytic AgentsChildHumansScoliosisAntifibrinolytic AgentsAntifibrinolytic agentsEpsilon aminocaproic acidPaediatric spine surgeryTranexamic acid

Identifiers

PMID30739188
OpenAlexW2913654504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.