Evidence map›Paper›PMID 30739145›Full record

ArticleSkeletal radiology2019

Central osteophytes develop in cartilage with abnormal structure and composition: data from the Osteoarthritis Initiative cohort.

Martin Kretzschmar, Ursula Heilmeier, Sarah C Foreman, Gabby B Joseph, Charles E McCulloch, Michael C Nevitt, Thomas M Link

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Skeletal radiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Interpretation of Cartilage Damage at Routine Clinical MRI: How to Match Arthroscopic Findings.Radiographics : a review publication of the Radiological Society of North America, Inc
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Martin KretzschmarMusculoskeletal and Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA. martin.kretzschmar@usb.ch.
Ursula HeilmeierMusculoskeletal and Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
Sarah C ForemanMusculoskeletal and Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
Gabby B JosephMusculoskeletal and Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
Charles E McCullochDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Michael C NevittDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Thomas M LinkMusculoskeletal and Quantitative Imaging Research Group, Department of Radiology & Biomedical Imaging, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA, 94107, USA.
University of California, San Francisco · US

Funding

Translation of Quantitative Imaging in OsteoarthritisP50AR060752 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SOUZA, RICHARD BRIAN · 2011 to 2015
$6.2M
UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MAJUMDAR, SHARMILA · 2014 to 2018
$3.0M
Impact of Weight loss on Knee Joint Biochemical and Structural DegenerationR01AR064771 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINK, THOMAS M · 2014 to 2019
$1.6M
T2 Relaxation Time of Knee Cartilage in the OAI Incidence SubcohortU01AR059507 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LINK, THOMAS M · 2010 to 2012
$499k
DATA COORDINATING CENTER FOR THE OSTEOARTHRITIS INITIATIVE-264022258N01AR022258 · NIAMS · UNIVERSITY OF CALIFORNIA SYS OFFICE/PRES · 2003 to 2003
–
NIAMS NIH HHS N01-AR-2-2258,N01-AR-2-2259, N01-AR-2-2260, N01-AR-2-2261, and N01-AR-2-2262NIAMS NIH HHS P50 AR060752NIAMS NIH HHS R01 AR064771NIAMS NIH HHS U01 AR059507NIAMS NIH HHS U01-AR059507 and P50-AR060752
6 · The paper itself

Abstract

objectiveTo investigate the natural history of central osteophytes (COs) by analyzing the structure and matrix composition of CO-associated cartilage using 3-T MRI at and 1-3 years before the onset of COs. MATERIALS AND

methodsBaseline, 4- and 6-year knee MRIs of 400 participants in the Osteoarthritis Initiative were screened for the appearance of new COs. Twenty-eight subjects developed 31 COs. Using MRIs at CO onset and 1-3 years before CO onset, cartilage T2 values were calculated for the local cartilage preceding COs and the surrounding cartilage. Cartilage lesions local to the site of COs and bone marrow edema like lesions (BMELs) subjacent to COs were graded using whole organ MRI scores (WORMS). Wilcoxon tests were used to compare T2 values from the local and the surrounding cartilage at each time point and to compare T2 and WORMS between time points. Knee symptoms were recorded during this period.

resultsAll subjects showed local cartilage lesions before the development of COs. Mean cartilage WORMS increased from 1.56 ± 0.66 a period of 3 years before to 2.39 ± 0.75 with onset of COs (p = 0.008). Local T2 values in the area of the later-appearing COs were significantly higher compared with T2 values of the surrounding cartilage 3 (p = 0.044) and 2 years earlier (p = 0.031) and with the onset of COs (p = 0.025). No significant increase in symptoms was found with the onset of COs.

conclusionThis study provides evidence that focal cartilage structural and compositional degeneration precedes COs. No significant aggravation of knee symptoms was reported during the evolution of COs.

Indexed as

Cartilage, ArticularCohort StudiesFemaleFollow-Up StudiesHumansKnee JointMagnetic Resonance ImagingMaleMiddle AgedOsteoarthritis, KneeOsteophyteCentral osteophytesKneeMRIOsteoarthritis

Identifiers

PMID30739145
PMCPMC8176650
OpenAlexW2911226652

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.