ArticleExperimental gerontology2019
Sex-specific stress tolerance, proteolysis, and lifespan in the invertebrate Tigriopus californicus.
Article in Experimental gerontology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
- These Boots Are Made for Walking: Sex-Specific Physiological and Metabolomic Strategies Reflect Male-Skewed Vulnerability to Ocean Warming in a Keystone Amphipod.Global change biology · 2026Article
- Shenrong Guben Huanshao Pill enhanced stress resistance and extended the lifespan of Caenorhabditis elegans by activating the oxidative stress system via the DAF-16/FOXO signaling pathway.Biogerontology · 2026Article
- Mechanisms underlining Kelp (Saccharina japonica) adaptation to relative high seawater temperature.BMC genomics · 2025Article
- Molecular consequences of mitochondrial replacement may be masked from organismal traits in Tigriopus californicus.PloS one · 2025Article
- Mitonuclear effects on sex ratio persist across generations in interpopulation hybrids.Journal of evolutionary biology · 2024Article
- Interactive effects of temperature and salinity on metabolism and activity of the copepod Tigriopus californicus.The Journal of experimental biology · 2024Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The role of mitochondria in sex- and age-specific gene expression in a species without sex chromosomes.bioRxiv : the preprint server for biology · 2023Article
- Developmental temperature alters the thermal sensitivity of courtship activity and signal-preference relationships, but not mating rates.Oecologia · 2023Article
- Mitochondrial effects on fertility and longevity inProceedings. Biological sciences · 2022Article
- Food deprivation exposes sex-specific trade-offs between stress tolerance and life span in the copepodEcology and evolution · 2022Article
- Heat Wave Intensity Drives Sublethal Reproductive Costs in a Tidepool Copepod.Integrative organismal biology (Oxford, England) · 2022Article
- Hypoxia tolerance, but not low pH tolerance, is associated with a latitudinal cline across populations of Tigriopus californicus.PloS one · 2022Article
- Elevated Salinity Rapidly Confers Cross-Tolerance to High Temperature in a Splash-Pool Copepod.Integrative organismal biology (Oxford, England) · 2022Article
- Antiaging function of Chinese pond turtle (Frontiers in nutrition · 2022Article
- Mitonuclear interactions alter sex-specific longevity in a species without sex chromosomes.Proceedings. Biological sciences · 2021Article
- Susceptibility of the Non-Targeted CrustaceanGenes · 2021Article
- Evidence for hybrid breakdown in production of red carotenoids in the marine invertebrate Tigriopus californicus.PloS one · 2021Article
- Deubiquitinase USP7 regulatesAging · 2020Article
- Sex differences in early transcriptomic responses to oxidative stress in the copepod Tigriopus californicus.BMC genomics · 2020Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Because stress tolerance and longevity are mechanistically and phenotypically linked, the sex with higher acute stress tolerance might be expected to also live longer. On the other hand, the association between stress tolerance and lifespan may be complicated by tradeoffs between acute tolerance and long-term survival. Here we use the copepod Tigriopus californicus to test for sex differences in stress resistance, proteolytic activity and longevity. Unlike many model organisms, this species does not have sex chromosomes. However, substantial sex differences were still observed. Females were found to have superior tolerance to a range of acute stressors (high temperature, high salinity, low salinity, copper and bisphenol A (BPA)) across a variety of treatments including different populations, pure vs. hybrid crosses, and different shading environments. Upregulation of proteolytic capacity - one molecular mechanism for responding to acute stress - was also found to be sexually dimorphic. In the combined stress treatment of chronic copper exposure followed by acute heat exposure, proteolytic capacity was suppressed for males. Females, however, maintained a robust proteolytic stress response. While females consistently showed greater tolerance to short-term stress, lifespan was largely equivalent between the two sexes under both benign conditions and mild thermal stress. Our findings indicate that short-term stress tolerance does not predict long-term survival under relatively mild conditions.
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