Evidence map›Paper›PMID 30738754›Full record

ReviewSeminars in fetal & neonatal medicine2019

Beyond the Finnegan scoring system: Novel assessment and diagnostic techniques for the opioid-exposed infant.

Davida M Schiff, Matthew R Grossman

Abstract readReview
In one paragraph

Review in Seminars in fetal & neonatal medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
9.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 57 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. A comparative study of two scoring systems for the assessment of neonatal abstinence syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  5. Association between NNNS-II profiles and pharmacological treatment in infants with prenatal opioid exposure.Journal of perinatology : official journal of the California Perinatal Association · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Increased risk of severe neonatal opioid withdrawal syndrome in pregnancies with low placental ABCB1 DNA methylation.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Delivery timing for the opioid-exposed infant.American journal of obstetrics & gynecology MFM · 2022
    Article
  19. Stigmatization of Pregnant Individuals with Opioid Use Disorder.Women's health reports (New Rochelle, N.Y.) · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Davida M SchiffDivision of General Academic Pediatrics, MassGeneral Hospital for Children, 125 Nashua St #8630, USA. Electronic address: Davida.Schiff@MGH.HARVARD.EDU.
Matthew R GrossmanYale School of Medicine, Department of Pediatrics, 333 Cedar St., PO Box 208064, New Haven, CT, 06520-8064, USA. Electronic address: matthew.grossman@yale.edu.
MaineGeneral Medical Center · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Career Development Program in Substance Use and Addiction MedicineK12DA043490 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI A EDEN EVINS, NANCY A RIGOTTI · 2017 to 2026
$4.7M
Mentoring in Addiction Treatment ResearchK24DA030443 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI EVINS, A EDEN · 2010 to 2020
$2.0M
Improving Treatment Engagement and Adherence to Optimize Outcomes for Opioid-Exposed Mother-Infant DyadsK23DA048169 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI SCHIFF, DAVIDA · 2019 to 2023
$998k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K12 DA043490NIDA NIH HHS K23 DA048169NIDA NIH HHS K24 DA030443
6 · The paper itself

Abstract

Infants with in-utero opioid exposure are most commonly assessed using the Finnegan Neonatal Abstinence Scoring System (FNASS) or a modified version of that tool. Traditionally, the purpose of these tools has been to characterize the extent of withdrawal signs to guide the pharmacologic treatment for infants with neonatal opioid withdrawal syndrome (NOWS). In the past decade however, in response to some of the limitations of the FNASS tool, there has been an increasing emphasis on developing novel assessment tools not based on the FNASS in addition to the promotion of non-pharmacologic treatment options as the first line treatment for infants with opioid exposure. Additionally, several prediction tools that may be useful in determining which patients are at high or low risk for receiving pharmacologic therapy have been developed. In this review, we will evaluate the clinical utility of these novel tools and will consider new avenues for future research.

Indexed as

Analgesics, OpioidHumansInfant, NewbornNeonatal Abstinence SyndromeAnalgesics, OpioidAssessmentDiagnostic toolsNAS, Neonatal abstinence syndromeNOWS, Neonatal opioid withdrawal syndrome

Identifiers

PMID30738754
PMCPMC6451877
OpenAlexW2914684460

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.