ArticleJournal of the American Academy of Child and Adolescent Psychiatry2019
Amygdala Functional Connectivity During Self-Face Processing in Depressed Adolescents With Recent Suicide Attempt.
Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- A Systematic Review of MRI Studies and the "Emotional paiN and social Disconnect (END)" Brain Model of Suicidal Behavior in Youth.Behavioural neurology · 2023Pooled it
- Immersive and reflective recall of a suicidal episode: Implications for assessing and treating suicidal adolescents.Journal of consulting and clinical psychology · 2023Trial
- Selective encoding failure of self-face identity in subthreshold depression.Psychological research · 2026Article
- Psychotic Symptoms Following Subthalamic DBS in Parkinson's Disease: Three Clinical Cases and Literature Review.Clinical case reports · 2026Article
- Alexithymia and self-harm in depressed adolescents: the mediating role of resting-state functional connectivity of the ventral hippocampal-fusiform gyrus.Annals of general psychiatry · 2026Article
- Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts.World journal of psychiatry · 2026Article
- Understanding the emergence of suicidal thoughts and behaviors in adolescence from a brain and behavioral developmental perspective.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Review
- Mechanistic Underpinnings of Emotional Face Processing in Suicide Risk: Exploring the Moderating Effects of Cortisol on Neural Parameters Using Magnetoencephalography.Psychiatric research and clinical practice · 2026Article
- Self-Processing Circuits Among Depressed Youth After Amygdala Neurofeedback Cued to the Self-Face.Journal of neuroscience research · 2025Article
- Mechanisms underlying the alleviation of negative emotions from social exclusion by interpersonal emotion regulation.Scientific reports · 2025Article
- Dynamic Functional Connectivity Between Amygdala and Cognitive Control Network Predicts Delay Discounting in Older Adolescents.Human brain mapping · 2025Article
- Psychoneuroimmunoendocrinological and neuroanatomical basis of suicidal behavior: potential therapeutic strategies with a focus on transcranial magnetic stimulation (TMS).Brain, behavior, & immunity - health · 2025Article
- Effects of Intermittent Fasting on Anxiety and the Functional Connectivity of the Amygdala in Healthy Adults.Alpha psychiatry · 2025Article
- Article
- Self-compassion, self-referential caudate circuitry, and adolescent suicide ideation.Translational psychiatry · 2024Article
- Functional connectivity density of different suicidal behaviors in adolescents with major depressive disorders.Frontiers in psychiatry · 2024Article
- Hypoactive Visual Cortex, Prefrontal Cortex and Insula during Self-Face Recognition in Adults with First-Episode Major Depressive Disorder.Biomedicines · 2023Article
- History of suicide attempt associated with amygdala and hippocampus changes among individuals with schizophrenia.European archives of psychiatry and clinical neuroscience · 2023Article
- Re-cognizing the new self: The neurocognitive plasticity of self-processing following facial transplantation.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
Corrections and comments
- Erratum issuedCorrection.2019
Authors and funding
5 authors.
Funding
Abstract
objectiveSuicide is the second leading cause of death among adolescents; however, objective biomarkers of suicide risk are lacking. Aberrant self-face amygdala activity is associated with suicide ideation, and its connectivity with neural regions that enable self-processing (eg medial prefrontal cortex) may be a suicide risk factor.
methodAdolescents (aged 11-17 years; N = 120) were sorted into four groups: healthy controls (HC), depressed individuals with low suicide ideation (LS), depressed individuals with high suicide ideation (HS), and depressed suicide attempters (SA). Youth completed an emotional (Happy, Sad, Neutral) self-face recognition task in the scanner. Bilateral amygdala task-dependent functional connectivity was determined with psychophysiological interaction analysis. Connectivity was compared across groups and within Self versus Other faces across emotions and hemispheres. Voxelwise results were thresholded (p < .005, uncorrected) and corrected for multiple comparisons (p < .05, familywise error).
resultsBoth HS and SA displayed greater amygdala connectivity with the dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, and precuneus, compared to LS, who, in turn, showed greater connectivity than HC. Greater left amygdala-rostral anterior cingulate cortex (rACC) connectivity was observed in SA compared to all other groups, whereas right amygdala-rACC connectivity was greater in HS versus LS and HC.
conclusionGreater connectivity between amygdala and other regions implicated in self-face processing differentiated suicide ideation and suicide attempt groups. A dose-dependent response showed that greater rACC-left amygdala connectivity during self-face processing was associated with a recent suicide attempt, but that a greater rACC-right amygdala connectivity was associated with suicide ideation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.