Evidence map›Paper›PMID 30738373›Full record

ArticleNeuroImage. Clinical2019

The structural brain correlates of callous-unemotional traits in incarcerated male adolescents.

Brendan M Caldwell, Nathaniel E Anderson, Keith A Harenski, Miranda H Sitney, Michael F Caldwell, Greg J Van Rybroek, Kent A Kiehl

Abstract read
In one paragraph

Article in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Brendan M CaldwellThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA. Electronic address: bcaldwell@mrn.org.
Nathaniel E AndersonThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Keith A HarenskiThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Miranda H SitneyThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA.
Michael F CaldwellMendota Juvenile Treatment Center, Madison, WI, USA.
Greg J Van RybroekUniversity of Wisconsin-Madison, Madison, WI, USA.
Kent A KiehlThe Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA. Electronic address: kkiehl@mrn.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Youth with severe conduct problems impose a significant cost on society by engaging in high levels of antisocial and aggressive behavior. Within this group, adolescents with high levels of callous- unemotional traits have been found to exhibit more severe and persistent patterns of antisocial behavior than youth with severe conduct problems but normative levels of callous-unemotional traits. Existing neuroimaging studies, along with theoretical accounts of psychopathology, suggest that dysfunction within the paralimbic cortex and limbic system may underlie elevated levels of callous-unemotional traits. The present study examines this hypothesis by investigating gray matter correlates associated with callous-unemotional traits. A sample of incarcerated male adolescents (N = 269), were assessed using voxel-based morphometry. Callous-unemotional traits were assessed using the Inventory of Callous-Unemotional traits (Frick 2004). Total callous-unemotional traits were negatively correlated with anterior temporal lobe gray matter volume (GMV). Callous traits in particular exhibited a reliable negative correlation with gray matter volume in nearly every paralimbic brain region examined. Uncaring traits were positively correlated with GMV in the orbitofrontal and anterior cingulate cortices. These findings demonstrate specific neural features within the paralimbic cortex and limbic system that accompany elevated callous-unemotional traits and serves to expand our understanding of pathophysiological mechanisms that may give rise to severe conduct problems in youth.

Indexed as

AdolescentAggressionAntisocial Personality DisorderBrainConduct DisorderHumansMagnetic Resonance ImagingMalePrisonersCallous-unemotional traitsConduct disorderGray matter volumeParalimbic system dysfunctionVoxel-based morphometry

Identifiers

PMID30738373
PMCPMC6370859

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.