ReviewNeuroImage. Clinical2019
Neurophysiological markers of network dysfunction in neurodegenerative diseases.
Review in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05378659 (Neuroinflammation and Alzheimer's Pathology in Post-operative Cognitive Dysfunction), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroinflammation and Alzheimer's Pathology in Post-operative Cognitive Dysfunction: A Pilot Study
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Standardized clinical assessments and advanced AI-driven instruments used to evaluate neurofunctional deficits, including within biomarker based framework, in Parkinson's disease - human intelligence made vs. AI models - systematic review.Frontiers in medicine · 2025Pooled it
- Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review.Alzheimer's research & therapy · 2024Pooled it
- The imaging signature of C9orf72 hexanucleotide repeat expansions: implications for clinical trials and therapy development.Brain imaging and behavior · 2021Pooled it
- Dietary Melatonin Therapy Alleviates the Lamina Cribrosa Damages in Patients with Mild Cognitive Impairments: A Double-Blinded, Randomized Controlled Study.Medical science monitor : international medical journal of experimental and clinical research · 2020Trial
- Very low-amplitude muscle activity increases probability of motor evoked potentials in healthy individuals and in amyotrophic lateral sclerosis.Experimental physiology · 2026Article
- Magnetoencephalography in human neuroscience research: planning, piloting, implementation and quality assurance.Nature protocols · 2026Review
- Long-interval intracortical inhibition is similar in people with and without amyotrophic lateral sclerosis.Brain communications · 2026Article
- Linking EEG markers of oscillopathy and default mode network dysfunction in Alzheimer's disease.Frontiers in human neuroscience · 2026Review
- Cerebral metabolic covariance in delirium: pattern response to symptomatic changes.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Topographic Variation in Human Neurotransmitter Receptor Densities Explains Differences in Intracranial EEG Spectra.Human brain mapping · 2025Article
- Characterizing the heterogeneity of neurodegenerative diseases through EEG normative modeling.NPJ Parkinson's disease · 2025Article
- Depletion of CD169Frontiers in neuroscience · 2025Article
- Beyond the usual suspects: multi-factorial computational models in the search for neurodegenerative disease mechanisms.Translational psychiatry · 2024Review
- Electroencephalographic β-band oscillations in the sensorimotor network reflect motor symptom severity in amyotrophic lateral sclerosis.European journal of neurology · 2024Article
- Contingent Negative Variation in the Evaluation of Neurocognitive Disorders Due to Possible Alzheimer's Disease.Neurology international · 2024Article
- Examining short interval intracortical inhibition with different transcranial magnetic stimulation-induced current directions in ALS.Clinical neurophysiology practice · 2024Article
- Biomarkers in amyotrophic lateral sclerosis: current status and future prospects.Nature reviews. Neurology · 2023Review
- Multiple neuron clusters on Micro-Electrode Arrays as an in vitro model of brain network.Scientific reports · 2023Article
- Paving the Way for Predicting the Progression of Cognitive Decline: The Potential Role of Machine Learning Algorithms in the Clinical Management of Neurodegenerative Disorders.Journal of personalized medicine · 2023Article
- Transcranial focused ultrasound stimulation of cortical and thalamic somatosensory areas in human.PloS one · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is strong clinical, imaging and pathological evidence that neurodegeneration is associated with altered brain connectivity. While functional imaging (fMRI) can detect resting and activated states of metabolic activity, its use is limited by poor temporal resolution, cost and confounding vascular parameters. By contrast, electrophysiological (e.g. EEG/MEG) recordings provide direct measures of neural activity with excellent temporal resolution, and source localization methodologies can address problems of spatial resolution, permitting measurement of functional activity of brain networks with a spatial resolution similar to that of fMRI. This opens an exciting therapeutic approach focussed on pharmacological and physiological modulation of brain network activity. This review describes current neurophysiological approaches towards evaluating cortical network dysfunction in common neurodegenerative disorders. It explores how modern neurophysiologic tools can provide markers for diagnosis, prognosis, subcategorization and clinical trial outcome measures, and how modulation of brain networks can contribute to new therapeutic approaches.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.