ReviewBiotechnology advances2019
On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.
Review in Biotechnology advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed.
- Comparative Phylogenomics Reveals Conserved Protoilludene Synthase Neighbourhoods and Unevenly Distributed Biosynthetic Gene Cluster Families in Armillaria.Journal of fungi (Basel, Switzerland) · 2026Article
- When growth becomes risky: stress-driven sporulation and sexual development in fungi.Stress biology · 2026Review
- Isolation of the new polyketide (-)-R-talaropinophiloic acid guided by an integrated metabolomics-dereplication approach.World journal of microbiology & biotechnology · 2026Article
- Climate-Driven Regulatory Plasticity Reshapes Mycotoxin Risk and Control in Food Systems.Comprehensive reviews in food science and food safety · 2026Review
- Population-level Variability in Genome-wide Repressive Histone Marks in a Fungal Wheat Pathogen.Genome biology and evolution · 2026Article
- Effect of epigenetic modulation on metabolites from endophytes isolated from Embelia ribes.International microbiology : the official journal of the Spanish Society for Microbiology · 2026Article
- Chemical Signaling and Metabolomic Crosstalk in Endophytic Fungi-Medicinal Plant Symbioses for Natural Product Discovery and Sustainable Bioproduction.Metabolites · 2026Review
- A metabolomics approach to target the effect of histone protein methyltransferase-specific probe UNC1999 on cryptic metabolites in an endophytic fungusFrontiers in microbiology · 2026Article
- Exploration of inactive metabolic pathways in AntarcticIMA fungus · 2026Article
- Review
- Comparative Proteomic Analysis ofJournal of fungi (Basel, Switzerland) · 2025Article
- Anti-neuroinflammatory polyketides from the medicinal herb-derived fungal strain Didymocyrtis brachylaenae Km1530.Journal of food and drug analysis · 2025Article
- Regulation and induction of fungal secondary metabolites: a comprehensive review.Archives of microbiology · 2025Review
- Exploring the modern approaches to enhance fungal endophyte-derived bioactive secondary metabolites.3 Biotech · 2025Review
- Unravelling fungal genome editing revolution: pathological and biotechnological application aspects.Archives of microbiology · 2025Review
- Effects of Magnaporthe oryzae cell-free filtrate on the secondary metabolism of Streptomyces bikiniensis HD-087: a non-targeted metabolomics analysis.Microbial cell factories · 2025Article
- Exploring the multifaceted roles of histone deacetylase inhibitor vorinostat in the cell growth, mycelial morphology, pigments, and citrinin biosynthesis of Monascus purpureus.Archives of microbiology · 2025Article
- Effect of Curcumin Pretreatment on the Susceptibility ofPharmaceuticals (Basel, Switzerland) · 2025Article
- Global Analysis of Natural Products Biosynthetic Diversity Encoded in Fungal Genomes.Journal of fungi (Basel, Switzerland) · 2024Article
- The histone deacetylase Hda1 affects oxidative and osmotic stress response as well as mycoparasitic activity and secondary metabolite biosynthesis inMicrobiology spectrum · 2024Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Fungi produce an abundance of bioactive secondary metabolites which can be utilized as antibiotics and pharmaceutical drugs. The genes encoding secondary metabolites are contiguously arranged in biosynthetic gene clusters (BGCs), which supports co-regulation of all genes required for any one metabolite. However, an ongoing challenge to harvest this fungal wealth is the finding that many of the BGCs are 'silent' in laboratory settings and lie in heterochromatic regions of the genome. Successful approaches allowing access to these regions - in essence converting the heterochromatin covering BGCs to euchromatin - include use of epigenetic stimulants and genetic manipulation of histone modifying proteins. This review provides a comprehensive look at the chromatin remodeling proteins which have been shown to regulate secondary metabolism, the use of chemical inhibitors used to induce BGCs, and provides future perspectives on expansion of epigenetic tools and concepts to mine the fungal metabolome.
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