ArticleJournal of diabetes investigation2019
Case of fulminant type 1 diabetes induced by the anti-programmed death-ligand 1 antibody, avelumab.
Article in Journal of diabetes investigation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 17 citations in OpenAlex.
- Article
- Clinical and immunological characteristics of PD-1 associated fulminant type 1 diabetes mellitus.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Sintilimab-induced autoimmune diabetes: A case report and review of the literature.World journal of clinical cases · 2022Article
- Two types of fulminant type 1 diabetes mellitus: Immune checkpoint inhibitor-related and conventional.Journal of diabetes investigation · 2021Article
- Immunotherapy-Associated Pancreatic Adverse Events: Current Understanding of Their Mechanism, Diagnosis, and Management.Frontiers in oncology · 2021Article
- Atezolizumab-induced type 1 diabetes mellitus in a patient with metastatic renal cell carcinoma.BMJ case reports · 2020Article
- Anti PD-1 monoclonal antibody induced autoimmune diabetes mellitus: a case report and brief review.Translational lung cancer research · 2020Article
- Case of fulminant type 1 diabetes induced by the anti-programmed death-ligand 1 antibody, avelumab.Journal of diabetes investigation · 2019Article
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8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the expansive use of immune checkpoint inhibitors, the frequency of immune-related adverse events, including autoimmune type 1 diabetes, has been exponentially increased. The anti-programmed death-ligand 1 antibody, avelumab, has recently been approved for metastatic Merkel cell carcinoma therapy. Here, we report a patient that developed fulminant type 1 diabetes during avelumab treatment. An 81-year-old woman with no history of diabetes received avelumab for metastatic Merkel cell carcinoma. Elevated plasma glucose level (483 mg/dL), hemoglobin A1c level (7.5%) and ketosis were observed after 10 courses of avelumab without any symptoms related to hyperglycemia. As the laboratory tests showed insulin depletion, we diagnosed her with fulminant type 1 diabetes induced by avelumab. This is the first reported case of avelumab-induced type 1 diabetes, illustrating the necessity for close monitoring of glycemic control during avelumab therapy, as well as other immune checkpoint inhibitors.
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