ArticleJournal of biomedical optics2019
Microscopy with ultraviolet surface excitation for wide-area pathology of breast surgical margins.
Article in Journal of biomedical optics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 54 citations in OpenAlex.
- Dual-scale and dual-channel oblique plane microscopy for multi-resolution imaging of large tissue specimens.Biomedical optics express · 2026Article
- Intraoperative measurement of breast-conserving surgery margins: surgical application.Breast cancer research : BCR · 2026Review
- Ultraviolet Sensing-Guided Biomedical Systems: From Label-Free Imaging to Dosimetry and Therapy Feedback.Biosensors · 2026Review
- Semantic Segmentation for Pixel-Wise Visualization of Breast Cancer in Deep Ultraviolet-Excited Fluorescence Images.Acta histochemica et cytochemica · 2026Article
- Rapid Arbitrary-Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Effective transfer of tumor annotations from hematoxylin and eosin to fluorescence images of breast and lung tissues.Journal of biomedical optics · 2026Article
- Metabolic light absorption, scattering, and emission (MetaLASE) microscopy.Science advances · 2024Article
- Visualization of Gastric Adenocarcinoma Lymph Node Metastases by Microscopy with Ultraviolet Surface Excitation.Sovremennye tekhnologii v meditsine · 2024Article
- Structured illumination microscopy for cancer identification in diagnostic breast biopsies.PloS one · 2024Article
- Miniature line-scanned dual-axis confocal microscope for versatile clinical use.Biomedical optics express · 2023Article
- Deep learning-enabled realistic virtual histology with ultraviolet photoacoustic remote sensing microscopy.Nature communications · 2023Article
- Comprehensive Surface Histology of Fresh Resection Margins With Rapid Open-Top Light-Sheet (OTLS) Microscopy.IEEE transactions on bio-medical engineering · 2023Article
- Rapid On-Site Microscopy and Mapping of Diagnostic Biopsies for See-And-Treat Guidance of Localized Prostate Cancer Therapy.Cancers · 2023Article
- Article
- Automated assessment of breast margins in deep ultraviolet fluorescence images using texture analysis.Biomedical optics express · 2022Article
- Virtual histological staining of label-free total absorption photoacoustic remote sensing (TA-PARS).Scientific reports · 2022Article
- Imaging peripheral nerve micro-anatomy with MUSE, 2D and 3D approaches.Scientific reports · 2022Article
- Prostate cancer histopathology using label-free multispectral deep-UV microscopy quantifies phenotypes of tumor aggressiveness and enables multiple diagnostic virtual stains.Scientific reports · 2022Article
- Intraoperative imaging in pathology-assisted surgery.Nature biomedical engineering · 2022Review
- Rapid slide-free and non-destructive histological imaging using wide-field optical-sectioning microscopy.Biomedical optics express · 2022Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
Intraoperative assessment of breast surgical margins will be of value for reducing the rate of re-excision surgeries for lumpectomy patients. While frozen-section histology is used for intraoperative guidance of certain cancers, it provides limited sampling of the margin surface (typically <1 % of the margin) and is inferior to gold-standard histology, especially for fatty tissues that do not freeze well, such as breast specimens. Microscopy with ultraviolet surface excitation (MUSE) is a nondestructive superficial optical-sectioning technique that has the potential to enable rapid, high-resolution examination of excised margin surfaces. Here, a MUSE system is developed with fully automated sample translation to image fresh tissue surfaces over large areas and at multiple levels of defocus, at a rate of ∼5 min / cm2. Surface extraction is used to improve the comprehensiveness of surface imaging, and 3-D deconvolution is used to improve resolution and contrast. In addition, an improved fluorescent analog of conventional H&E staining is developed to label fresh tissues within ∼5 min for MUSE imaging. We compare the image quality of our MUSE system with both frozen-section and conventional H&E histology, demonstrating the feasibility to provide microscopic visualization of breast margin surfaces at speeds that are relevant for intraoperative use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.