Observational studyBritish journal of clinical pharmacology2019
Patterns of gabapentin and pregabalin use and misuse: Results of a population-based cohort study in France.
Observational study in British journal of clinical pharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 104 citations in OpenAlex.
- Pooled it
- Pregabalin-associated adverse drug reactions: A real-world pharmacovigilance study using WHO-VigiAccess.Medicine · 2026Article
- Classic Psychedelics for Treating Chronic Pain: Mechanism and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Impact of secured prescription implementation on ambulatory pregabalin use in France: A regional assessment in the French Nouvelle-Aquitaine.British journal of clinical pharmacology · 2026Article
- Daily Doses of Gabapentinoids for Pain Management Among Opioid Users Aged Below and Above 65 years.Clinical medicine & research · 2026Article
- Prevalence and Patterns of Non-Medical Gabapentinoid Use in a General Population Sample: Findings From the Australian National Drug Strategy Household Survey.Drug and alcohol review · 2026Article
- A hospital-based multi-centric observational study to explore the prevalence and correlates of non-medical use and dependence of pregabalin among the patients with substance use disorder in Punjab & Chandigarh.Substance abuse treatment, prevention, and policy · 2026Observational
- Pregabalin dependence, withdrawal, suicidality and psychosis reports: A disproportionality analysis of the Australian adverse events database.British journal of clinical pharmacology · 2026Article
- Association Between Opioid Analgesics and Suicide Attempts: A Nationwide French Case-Crossover Study.CNS drugs · 2025Observational
- Article
- Patterns of Analgesic Prescribing and High-Risk Prescribing in Primary Care in Ireland 2014-2022-A Repeated Cross-Sectional Study.European journal of pain (London, England) · 2025Article
- High-dose use of pregabalin and gabapentin in France: a retrospective, population-based cohort study.The Lancet regional health. Europe · 2025Article
- Changing Trends in Nonmedical Gabapentin Use Among a Cohort of Rural Appalachian People Who Use Drugs: A Longitudinal Study Over the Time Period of Scheduling Changes in Kentucky.The International journal on drug policy · 2025Article
- Addressing Gabapentinoids' Access Challenges in Saudi Arabia Under New Prescription Regulations: An Expert View.Pain and therapy · 2025Review
- A Review on the Management of Symptoms in Patients with Incurable Cancer.Current oncology (Toronto, Ont.) · 2025Review
- How Should Non-Prescribed Use of Gabapentinoids be Reduced in Psychiatric Practice?Human psychopharmacology · 2025Article
- Trends in Drug Claims for Non-Specific Low Back Pain in Québec, 1997 to 2018.Musculoskeletal care · 2025Article
- On Patient Safety: It Is Time to Rethink Gabapentin.Clinical orthopaedics and related research · 2025Article
- Community pharmacists' engagement with Raqeeb platform: perceptions and implementation challenges toward controlled substance monitoring in Saudi Arabia.Frontiers in pharmacology · 2025Article
- A case report of pregabalin misuse leading to drug dependence.Frontiers in psychiatry · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe aim of this study was to assess the use and factors associated with the misuse of gabapentin and pregabalin in the general French population, through a cohort study in the EGB (General Sample of Beneficiaries), a national representative sample of the French general population.
methodsNew users of gabapentin and pregabalin were identified from June 2006 to December 2014, and new users of duloxetine served as control group. Misuse was defined as a use of higher daily doses than recommended. Cox proportional hazard regression models were performed to identify associated factors of misuse.
resultsMisuse was more frequent in the 8692 new users of pregabalin (12.8%) than in the 1963 gabapentin (6.6%) or the 3214 duloxetine new users (9.7%) (P < 0.001). Factors associated with misuse were pregabalin (hazard ratio [HR] 1.48; 95% confidence interval [CI] [1.29-1.69]), age (HR
conclusionIn a cohort of new users, misuse is more likely to occur in new users of pregabalin, with different associated factors of misuse compared to gabapentin and duloxetine. Health professionals and prescribers must be aware of this misuse potential, which could lead to abuse and dependence.
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