Evidence map›Paper›PMID 30737811›Full record

ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2019

Quantifying Complex Micro-Topography of Degenerated Articular Cartilage Surface by Contrast-Enhanced Micro-Computed Tomography and Parametric Analyses.

Tuomo Ylitalo, Mikko A J Finnilä, Harpal K Gahunia, Sakari S Karhula, Heikki Suhonen, Maarit Valkealahti, Petri Lehenkari, Edward Haeggström, Kenneth P H Pritzker, Simo Saarakkala and 1 more

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Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tuomo YlitaloResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Mikko A J FinniläResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Harpal K GahuniaOrthopedic Science Consulting Services, Oakville, Ontario, Canada.
Sakari S KarhulaResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Heikki SuhonenDepartment of Physics, University of Helsinki, Helsinki, Finland.
Maarit ValkealahtiDepartment of Surgery and Intensive Care, University of Oulu and Oulu University Hospital, Oulu, Finland.
Petri LehenkariMedical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
Edward HaeggströmDepartment of Physics, University of Helsinki, Helsinki, Finland.
Kenneth P H PritzkerDepartment of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Canada.
Simo SaarakkalaResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.
Heikki J NieminenResearch Unit of Medical Imaging, Physics and Technology, Faculty of Medicine, University of Oulu, Oulu, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

One of the earliest changes in osteoarthritis (OA) is a surface discontinuity of the articular cartilage (AC), and these surface changes become gradually more complex with OA progression. We recently developed a contrast enhanced micro-computed tomography (μCT) method for visualizing AC surface in detail. The present study aims to introduce a μCT analysis technique to parameterize these complex AC surface features and to demonstrate the feasibility of using these parameters to quantify degenerated AC surface. Osteochondral plugs (n = 35) extracted from 19 patients undergoing joint surgery were stained with phosphotungstic acid and imaged using μCT. The surface micro-topography of AC was analyzed with developed method. Standard root mean square roughness (R

Indexed as

Phosphotungstic AcidAgedAged, 80 and overCartilage, ArticularFemaleHumansMaleMiddle AgedOsteoarthritisX-Ray MicrotomographyPhosphotungstic Acid3D imagingarticular cartilagemicrocomputed X-ray tomographysurface roughnesstopography

Identifiers

PMID30737811
PMCPMC6518937

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.