Evidence map›Paper›PMID 30737679›Full record

ArticleEuropean journal of epidemiology2019

The association between weight at birth and breast cancer risk revisited using Mendelian randomisation.

Siddhartha P Kar, Irene L Andrulis, Hermann Brenner, Stephen Burgess, Jenny Chang-Claude, Daniel Considine, Thilo Dörk, Dafydd Gareth R Evans, Manuela Gago-Domínguez, Graham G Giles and 17 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of epidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 18 institutions in 10 countries.

Siddhartha P KarDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK. sk718@medschl.cam.ac.uk.ORCID http://orcid.org/0000-0002-2314-1426
Irene L AndrulisFred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
Hermann BrennerDivision of Clinical Epidemiology and Ageing Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Stephen BurgessDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Daniel ConsidineDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Thilo DörkGynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Dafydd Gareth R EvansDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine, and Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Manuela Gago-DomínguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saude (SERGAS), Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago De Compostela, Spain.
Graham G GilesCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Mikael HartmanSaw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore.
Dezheng HuoDepartment of Public Health Sciences, University of Chicago, Chicago, IL, USA.
Rudolf KaaksDivision of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Jingmei LiHuman Genetics, Genome Institute of Singapore, Singapore, Singapore.
Artitaya LophatananonDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Sara MargolinDepartment of Oncology, Södersjukhuset and Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Roger L MilneCancer Epidemiology and Intelligence Division, Cancer Council Victoria, Melbourne, VIC, Australia.
Kenneth R MuirDivision of Population Health, Health Services Research and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.
Håkan OlssonDepartment of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
Kevin PunieDepartment of Oncology, Leuven Multidisciplinary Breast Centre, University Hospital Leuven, KU Leuven, Louvain, Belgium.
Paolo RadiceUnit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
Jacques SimardGenomics Center, Centre Hospitalier Universitaire de Québec - Université Laval Research Center, Quebec City, QC, Canada.
Rulla M TamimiDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Els Van NieuwenhuysenDepartment of Oncology, Leuven Multidisciplinary Breast Centre, University Hospital Leuven, KU Leuven, Louvain, Belgium.
Camilla WendtDepartment of Oncology, Södersjukhuset and Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, TN, USA.
Paul D P PharoahDepartment of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
University of Cambridge · GBManchester Academic Health Science Centre · GBGerman Cancer Research Center · DEKarolinska Institutet · SEKU Leuven · BEThe University of Melbourne · AUBrigham and Women's Hospital · USCentre hospitalier universitaire de Québec · CAChicago Department of Public Health · USFondazione IRCCS Istituto Nazionale dei Tumori · ITGenome Institute of Singapore · SGLund University · SEMedizinische Hochschule Hannover · DEMount Sinai Hospital · CANational University of Singapore · SGUniversität Hamburg · DEUniversity of California San Diego · USVanderbilt University · US

Funding

British Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Cancer Research UK 10119Cancer Research UK 10124Cancer Research UK 16561Department of Health RP-PG-0707-10031Department of Health RP-PG-1214-20016Medical Research Council MC_UU_00002/7Wellcome Trust 204623/Z/16/Z
6 · The paper itself

Abstract

Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10

Indexed as

Birth WeightBreast NeoplasmsFemaleHumansMendelian Randomization AnalysisPolymorphism, Single NucleotideRisk AssessmentBirth weightBreast cancerMendelian randomisation

Identifiers

PMID30737679
PMCPMC6497616
OpenAlexW2900131894

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.