ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2019
Mutations in the SPAST gene causing hereditary spastic paraplegia are related to global topological alterations in brain functional networks.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- Motor Evoked Potentials in Hereditary Spastic Paraplegia-A Systematic Review.Frontiers in neurology · 2019Pooled it
- Subclinical involvement of central nervous system structures other than motor or sensory tracts in SPG3A and SPG4 patients.BMC neurology · 2026Article
- The Effect of Sleep Deprivation on Brain Fingerprint Stability: A Magnetoencephalography Validation Study.Sensors (Basel, Switzerland) · 2024Article
- Brain flexibility increases during the peri-ovulatory phase as compared to early follicular phase of the menstrual cycle.Scientific reports · 2024Article
- Flexibility of Fast Brain Dynamics and Disease Severity in Amyotrophic Lateral Sclerosis.Neurology · 2022Article
- A night of sleep deprivation alters brain connectivity and affects specific executive functions.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Functional brain network topology across the menstrual cycle is estradiol dependent and correlates with individual well-being.Journal of neuroscience research · 2021Article
- Thalamic atrophy in patients with pure hereditary spastic paraplegia type 4.Journal of neurology · 2021Article
- Flexible brain dynamics underpins complex behaviours as observed in Parkinson's disease.Scientific reports · 2021Article
- Rare Neurologic Diseases and Neurological Sciences: a report for the celebration of the 2020 Rare Diseases Day.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Article
- Neuronal Avalanches to Study the Coordination of Large-Scale Brain Activity: Application to Rett Syndrome.Frontiers in psychology · 2020Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimOur aim was to describe the rearrangements of the brain activity related to genetic mutations in the SPAST gene.
methodsTen SPG4 patients and ten controls underwent a 5 min resting state magnetoencephalography recording and neurological examination. A beamformer algorithm reconstructed the activity of 90 brain areas. The phase lag index was used to estimate synchrony between brain areas. The minimum spanning tree was used to estimate topological metrics such as the leaf fraction (a measure of network integration) and the degree divergence (a measure of the resilience of the network against pathological events). The betweenness centrality (a measure to estimate the centrality of the brain areas) was used to estimate the centrality of each brain area.
resultsOur results showed topological rearrangements in the beta band. Specifically, the degree divergence was lower in patients as compared to controls and this parameter related to clinical disability. No differences appeared in leaf fraction nor in betweenness centrality.
conclusionMutations in the SPAST gene are related to a reorganization of the brain topology.
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