Evidence map›Paper›PMID 30737488›Full record

ReviewNature reviews. Microbiology2019

Methicillin-resistant Staphylococcus aureus: an overview of basic and clinical research.

Nicholas A Turner, Batu K Sharma-Kuinkel, Stacey A Maskarinec, Emily M Eichenberger, Pratik P Shah, Manuela Carugati, Thomas L Holland, Vance G Fowler

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 970 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
970citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

970 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. The evolving landscape ofFrontiers in immunology · 2026
    Pooled it
  6. Trial
  7. Article
  8. Review
  9. New microbes and new infections · 2026
    Review
  10. Article
  11. Article
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  17. Review
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  19. Antibacterial and Antibiofilm Activity ofJournal of fungi (Basel, Switzerland) · 2026
    Article
  20. Article

910 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas A TurnerDuke University Medical Center, Durham, NC, USA.
Batu K Sharma-KuinkelDuke University Medical Center, Durham, NC, USA.
Stacey A MaskarinecDuke University Medical Center, Durham, NC, USA.
Emily M EichenbergerDuke University Medical Center, Durham, NC, USA.
Pratik P ShahDuke University Medical Center, Durham, NC, USA.
Manuela CarugatiDuke University Medical Center, Durham, NC, USA.
Thomas L HollandDuke University Medical Center, Durham, NC, USA.
Vance G FowlerDuke University Medical Center, Durham, NC, USA. vance.fowler@duke.edu.

Funding

Antibacterial Resistance Leadership Group (ARLG)UM1AI104681 · NIAID · DUKE UNIVERSITY · PI Vance G. Fowler, Henry F HENRY CHAMBERS · 2013 to 2026
$180.8M
Systems Immunolobiology of Antibiotic-Persistent MRSA InfectionU01AI124319 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI YEAMAN, MICHAEL R · 2016 to 2020
$10.1M
Institutional Career Development CoreKL2TR002554 · NCATS · DUKE UNIVERSITY · PI SVETKEY, LAURA P · 2018 to 2022
$8.2M
Host Susceptibility to S. aureusR01AI068804 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2007 to 2016
$6.9M
Mentoring Patient Oriented Research in Antibiotic-Resistant BacteriaK24AI093969 · NIAID · DUKE UNIVERSITY · PI FOWLER, VANCE G. · 2011 to 2020
$1.6M
Data commons for 'omic, microscopy and analysis core facilitiesS10OD018164 · OD · DUKE UNIVERSITY · PI WRAY, GREGORY A. · 2014 to 2014
$598k
NCATS NIH HHS KL2 TR002554NIAID NIH HHS K24 AI093969NIAID NIH HHS R01 AI068804NIAID NIH HHS U01 AI124319NIAID NIH HHS UM1 AI104681NIH HHS S10 OD018164
6 · The paper itself

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful modern pathogens. The same organism that lives as a commensal and is transmitted in both health-care and community settings is also a leading cause of bacteraemia, endocarditis, skin and soft tissue infections, bone and joint infections and hospital-acquired infections. Genetically diverse, the epidemiology of MRSA is primarily characterized by the serial emergence of epidemic strains. Although its incidence has recently declined in some regions, MRSA still poses a formidable clinical threat, with persistently high morbidity and mortality. Successful treatment remains challenging and requires the evaluation of both novel antimicrobials and adjunctive aspects of care, such as infectious disease consultation, echocardiography and source control. In this Review, we provide an overview of basic and clinical MRSA research and summarize the expansive body of literature on the epidemiology, transmission, genetic diversity, evolution, surveillance and treatment of MRSA.

Indexed as

Anti-Bacterial AgentsBacteremiaClinical Trials as TopicCommunity-Acquired InfectionsCross InfectionEvolution, MolecularGenetic VariationHumansIncidenceMethicillinMethicillin-Resistant Staphylococcus aureusSoft Tissue InfectionsStaphylococcal InfectionsAnti-Bacterial AgentsMethicillin

Identifiers

PMID30737488
PMCPMC6939889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.