ArticleScientific reports2019
Neuronal plasticity affects correlation between the size of dendritic spine and its postsynaptic density.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers.
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Who cites it
69 citing papers in PubMed, 134 citations in OpenAlex.
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- Dynamic recruitment of CaMKII into SHANK3 phase-separated condensates tunes postsynaptic density remodeling during long-term potentiation.Nature communications · 2026Article
- Alternatively spliced STIM2.3 is an evolutionarily late store-operated Ca2+ entry regulator expressed in brain.Journal of cell science · 2026Article
- Sleep deprivation alters hippocampal dendritic spines in a contextual fear memory engram.Scientific reports · 2026Article
- Cerebrolysin Ameliorates Age-Induced Dendritic Spine Degeneration and Memory Decline in C57BL6 Mice.Neurochemical research · 2025Article
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- Impaired Synaptic Plasticity Mediated by Decreased GLUT1 in Hippocampal Astrocytes is Involved in Postoperative Cognitive Dysfunction in Elderly Mice.Molecular neurobiology · 2025Article
- A unifying mechanism for presynaptic homeostatic plasticity at mammalian peripheral and central synapses.Neuron · 2025Article
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- Brief sleep disruption following hippocampus-dependent learning downscales interneuron synapses within lateral entorhinal cortex.bioRxiv : the preprint server for biology · 2025Article
- CDK5-mediated hyperphosphorylation of Tau217 impairs neuronal synaptic structure and exacerbates cognitive impairment in Alzheimer's disease.Translational psychiatry · 2025Article
- Lysine myristoylation mediates long-term potentiation via membrane enrichment of synaptic plasticity effectors.The EMBO journal · 2025Article
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- Molecular and Anatomical Strengthening of "Winner" Climbing Fiber Synapses in Developing Mouse Purkinje Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Synaptic cleft geometry modulates NMDAR opening probability by tuning neurotransmitter residence time.Biophysical journal · 2025Article
- Dynein-driven regulation of postsynaptic membrane architecture and synaptic function.Journal of cell science · 2025Article
- Mitofilin-mtDNA Axis Mediates Chronic Lead Exposure-Induced Synaptic Plasticity Impairment of Hippocampal and Cognitive Deficits.Biomolecules · 2025Article
- Brief sleep disruption alters synaptic structures among hippocampal and neocortical somatostatin-expressing interneurons.bioRxiv : the preprint server for biology · 2025Article
9 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Structural plasticity of dendritic spines is thought to underlie memory formation. Size of a dendritic spine is considered proportional to the size of its postsynaptic density (PSD), number of glutamate receptors and synaptic strength. However, whether this correlation is true for all dendritic spine volumes, and remains stable during synaptic plasticity, is largely unknown. In this study, we take advantage of 3D electron microscopy and reconstruct dendritic spines and cores of PSDs from the stratum radiatum of the area CA1 of organotypic hippocampal slices. We observe that approximately 1/3 of dendritic spines, in a range of medium sizes, fail to reach significant correlation between dendritic spine volume and PSD surface area or PSD-core volume. During NMDA receptor-dependent chemical long-term potentiation (NMDAR-cLTP) dendritic spines and their PSD not only grow, but also PSD area and PSD-core volume to spine volume ratio is increased, and the correlation between the sizes of these two is tightened. Further analysis specified that only spines that contain smooth endoplasmic reticulum (SER) grow during cLTP, while PSD-cores grow irrespectively of the presence of SER in the spine. Dendritic spines with SER also show higher correlation of the volumetric parameters than spines without SER, and this correlation is further increased during cLTP only in the spines that contain SER. Overall, we found that correlation between PSD surface area and spine volume is not consistent across all spine volumes, is modified and tightened during synaptic plasticity and regulated by SER.
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