ArticleScientific reports2019
Re-evaluation of transcription factor function in tomato fruit development and ripening with CRISPR/Cas9-mutagenesis.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 1 of them a synthesis that pooled it.
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Who cites it
92 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.
- Genome editing for vegetable crop improvement: Challenges and future prospects.Frontiers in genetics · 2022Pooled it
- Managing Trait Trade-Offs in Tomato Breeding Through Genome Editing.Plants (Basel, Switzerland) · 2026Review
- Genome Editing in Solanaceae: Harnessing CRISPR-Cas Technology for Precision Crop Improvement.Plants (Basel, Switzerland) · 2026Review
- CpERF-WRI1 Manipulates Ethylene Sensing by Regulating the Expression of CpERS1 and Fruit Ripening in Papaya.Plant biotechnology journal · 2026Article
- Tandem MADS-Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit.Plant biotechnology journal · 2026Article
- The carotenoids metabolism during tomato fruit ripening: insights into multi-level regulatory network.BMC plant biology · 2026Review
- Dual benefits ofHorticulture research · 2026Article
- Transcriptional control of tomato fruit development and ripening.Journal of experimental botany · 2025Review
- Allelic value in gene regulation-implications for gene editing.Annals of botany · 2025Article
- Article
- A comprehensive model of tomato fruit ripening regulation by the transcription factors NOR-like1, NAC-NOR, and MADS-RIN.Plant physiology · 2025Article
- Spatial regulation of chlorophyll degradation in kiwifruit: AcNAC2-AcSGR1/2 cascades mediate rapid de-greening in the inner pericarp.Plant biotechnology journal · 2025Article
- Slow and steady wins the race: the negative regulators of ethylene biosynthesis in horticultural plants.Horticulture research · 2025Article
- SlPLT6 controls ripening initiation and quality traits through modulation of histone acetylation and methylation in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- CRISPR mediated gene editing for economically important traits in horticultural crops: progress and prospects.Transgenic research · 2025Review
- Two transcription factors play critical roles in mediating epigenetic regulation of fruit ripening in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Solanaceae pan-genomes reveal extensive fractionation and functional innovation of duplicated genes.Plant communications · 2025Article
- Removal of toxic steroidal glycoalkaloids and bitterness in tomato is controlled by a complex epigenetic and genetic network.Science advances · 2025Article
- Article
- An advanced 10K SNP panel for genotyping tomato (Frontiers in plant science · 2025Article
32 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tomato (Solanum lycopersicum) is a model for climacteric fleshy fruit ripening studies. Tomato ripening is regulated by multiple transcription factors together with the plant hormone ethylene and their downstream effector genes. Transcription Factors APETALA2a (AP2a), NON-RIPENING (NOR) and FRUITFULL (FUL1/TDR4 and FUL2/MBP7) were reported as master regulators controlling tomato fruit ripening. Their proposed functions were derived from studies of the phenotype of spontaneous mutants or RNAi knock-down lines rather than, as it appears now, actual null mutants. To study TF function in tomato fruit ripening in more detail, we used CRISPR/Cas9-mediated mutagenesis to knock out the encoding genes, and phenotypes of these mutants are reported for the first time. While the earlier ripening, orange-ripe phenotype of ap2a mutants was confirmed, the nor null mutant exhibited a much milder phenotype than the spontaneous nor mutant. Additional analyses revealed that the severe phenotype in the spontaneous mutant is caused by a dominant-negative allele. Our approach also provides new insight into the independent and overlapping functions of FUL1 and FUL2. Single and combined null alleles of FUL1 and FUL2 illustrate that these two genes have partially redundant functions in fruit ripening, but also unveil an additional role for FUL2 in early fruit development.
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